International Journal of Preventive Medicine (Int J Prev Med)2008-78024120130505147158ENDepartment of Neurology, Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Neurology, Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Neurology, Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Neurology, Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran20130505<p><strong>Background: </strong>A variety of techniques for the management of spasticity have been suggested, including positioning, cryotherapy, splinting and casting, biofeedback, electrical stimulation, and medical management by pharmacological agents, Botulinum toxin A (BTA) is now the pharmacological treatment of choice in focal spasticity. BTA by blocking acetylcholine release at neuromuscular junctions accounts for its therapeutic action to relieve spasticity.</p> <p><strong>Methods: </strong>A computerized search of Pub Med was carried out to find the latest result about efficacy of BTA in management of post stroke spasticity.</p> <p><strong>Result: </strong>Among 84 articles were found, frothy of them included in this review and divided to lower and upper extremity.</p> <p><strong>Conclusions: </strong>BTA is a treatment choice in reducing tone and managing post stroke spasticity<strong>. </strong></p> <strong>Keywords: </strong>Botulinum toxin A, spasticity, strokehttp://ijpm.mui.ac.ir/index.php/ijpm/article/view/1159http://ijpm.mui.ac.ir/index.php/ijpm/article/download/1159/946