International Journal of Preventive Medicine (Int J Prev Med)2008-78022420110509142142ENMD, Department of Infectious and Tropical Diseases, Isfahan University of Medical Sciences, Isfahan, Iran.MD, Department of Infectious and Tropical Diseases, Isfahan University of Medical Sciences, Isfahan, Iran.MD, Department of Rheumatology, Isfahan University of Medical Sciences, Isfahan, Iran.MD, Department of Infectious and Tropical Diseases, Isfahan University of Medical Sciences, Isfahan, Iran.201103152011050320110414<p class="abstract">Systemic lupus erythematosus (SLE) is a chronic inflammatory disease of unknown cause. In this study, we report a case of SLE that was presented with persistent vomiting and liver involvement. To our knowledge, this is the first description of a patient with hepatic necrosis as the initial presentation of SLE in a previously healthy woman without any significant past medical history. In the literature, we found few cases of SLE with liver necrosis. In addition, all the cases found had a past medical history of a missed abortion or other complications of the disease. Therefore, if a young woman presents hepatic necrosis with a background of a previously missed abortion, it is better to perform anti-nuclear antibody (ANA) and anticardiolipin antibody tests as a preventive method for early diagnosis and early treatment.</p><p class="abstract"><strong>Keywords:</strong> Hepatitis, Systemic lupus erythematosus, Hepatic necrosis.</p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/142http://ijpm.mui.ac.ir/index.php/ijpm/article/download/142/362