Protective Effect of Hydroalcoholic Extract of Tribulus Terrestris on Cisplatin Induced Renal Tissue Damage in Male Mice

International Journal of Preventive Medicine (Int J Prev Med)2008-78020120150217Protective Effect of Hydroalcoholic Extract of Tribulus Terrestris on Cisplatin Induced Renal Tissue Damage in Male Mice14761476EN20150217Background: According benefcial effects of  Tribulus terrestris  (TT) extract on  tissue damage, the present study investigated the infuence of hydroalcoholic extract of TT plant on cisplatin (CIS) (EBEWE Pharma, Unterach, Austria) induced renal tissue damage in male mice. Methods: Thirty mice were divided into five groups (n = 6). The first group (control) was treated with normal saline (0.9% NaCl) and experimental groups with CIS (E1), CIS + 100 mg/kg extract of TT (E2), CIS + 300 mg/kg extract of TT (E3), CIS + 500 mg/kg extract of TT (E4) intraperitoneally. The  kidneys were  removed  after  4  days  of  injections,  and  histological evaluations were performed. Results: The data were analyzed using one‑way analysis of variance followed by Tukey’s post‑hoc test, paired‑sample t‑test, Kruskal–Wallis and Mann–Whitney tests. In the CIS treated group, the whole kidney tissue showed an increased dilatation of Bowman’s capsule, medullar congestion, and dilatation of collecting tubules and a decreased in the body weight and kidney weight. These parameters reached to the normal range after administration of fruit extracts of TT for 4 days. Conclusions: The results suggested that the oral administration of TT fruit extract at dose 100, 300 and 500 mg/kg body weight provided protection against the CIS induced toxicity in the mice. Keywords: Cisplatin, mice, nephrotoxicity, Tribulus terrestrishttp://ijpm.mui.ac.ir/index.php/ijpm/article/view/1476http://ijpm.mui.ac.ir/index.php/ijpm/article/download/1476/1758