International Journal of Preventive Medicine (Int J Prev Med)2008-7802042015072215551555EN20150721<strong>Background:</strong> The objective of this study was to determine the favorable effects of multi mineral‑Vitamin D supplementation on pregnancy outcomes among women at risk for pre‑eclampsia.<br /><strong>Methods:</strong> This randomized double‑blind controlled clinical trial was conducted among 46 women at risk for pre‑eclampsia at 27 weeks&rsquo; gestation with positive roll‑over test. Pregnant women<br />were randomly assigned to receive either the multi mineral‑Vitamin D supplements (n = 23) or the placebo (n =23) for 9‑week. Multi mineral‑Vitamin D supplements were containing 800 mg calcium, 200 mg magnesium, 8 mg zinc, and 400 IU Vitamin D3. Fasting blood samples were taken at baseline and after 9‑week intervention to measure related factors. Newborn&rsquo;s outcomes were determined.<br /><strong>Results:</strong> Although no significant difference was seen in newborn&rsquo;s weight and head circumference between the two groups, mean newborns&rsquo; length (51.3 &plusmn; 1.7 vs. 50.3 &plusmn; 1.2 cm, P = 0.03) was significantly higher in multi mineral‑Vitamin D group than that in the placebo group. Compared to the placebo, consumption of multi mineral‑Vitamin D supplements resulted in increased levels of serum calcium (+0.19 vs. &minus;0.08 mg/dL, P = 0.03), magnesium (+0.15 vs. &minus;0.08 mg/dL, P = 0.03),<br />zinc (+8.25 vs. &minus;21.38 mg/dL, P = 0.001) and Vitamin D (+3.79 vs. &minus;1.37 ng/ml, P = 0.01). In addition, taking multi mineral‑Vitamin D supplements favorably influenced systolic blood pressure (SBP) (&minus;1.08 vs. 6.08 mmHg, P = 0.001) and diastolic blood pressure (DBP) (&minus;0.44 vs. 3.05 mmHg, P = 0.02).<br /><strong>Conclusions:</strong> Multi mineral‑Vitamin D supplementation for 9‑week in pregnant women at risk for pre‑eclampsia resulted in increased newborn&rsquo;s length, increased circulating levels of maternal serum calcium, magnesium, zinc and Vitamin D, and led to decreased maternal SBP and DBP.<br /><strong>Keywords:</strong> Multi mineral‑Vitamin D supplementation, pre‑eclampsia, pregnancy outcomeshttp://ijpm.mui.ac.ir/index.php/ijpm/article/view/1555http://ijpm.mui.ac.ir/index.php/ijpm/article/download/1555/1847