Effects of Probiotics on Biomarkers of Oxidative Stress and Inflammatory Factors in Petrochemical Workers: A Randomized, Double-blind, Placebo-controlled Trial

International Journal of Preventive Medicine (Int J Prev Med)2008-78021220150902Effects of Probiotics on Biomarkers of Oxidative Stress and Inflammatory Factors in Petrochemical Workers: A Randomized, Double-blind, Placebo-controlled Trial15751575ENDepartment of Nutrition, School of Public Health, Iran University of Medical Sciences, TehranDepartment of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran1Research Department of Food Technology, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, TehranSchool of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, TehranSchool of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, TehranResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, KashanSchool of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, TehranSchool of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, TehranDepartment of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, TehranDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, TehranDepartment of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran20150902Background: The aim of the current study was to determine effects of probiotic yoghurt and multispecies probiotic capsule supplementation on biomarkers of oxidative stress and inflammatory factors in petrochemical workers.Methods: This randomized, double-blind, placebo-controlled trial was done among petrochemical workers. Subjects were randomly divided into three groups to receive 100 g/day probiotic yogurt (n = 12) or one probiotic capsule daily (n = 13) or 100 g/day conventional yogurt (n = 10) for 6 weeks. The probiotic yoghurt was containing two strains of Lactobacillus acidophilus and Bifidobacterium lactis with a total of min 1 × 107 CFU. Multispecies probiotic capsule contains seven probiotic bacteria spices Actobacillus casei 3 × 103 , L. acidophilus 3 × 107 , Lactobacillus rhamnosus 7 × 109 , Lactobacillus bulgaricus 5 × 108 , Bifidobacterium breve 2 × 1010, Bifidobacterium longum 1 × 109 and Streptococcus thermophilus 3 × 108 CFU/g. Fasting blood samples were obtained at the beginning and end of the trial to quantify biomarkers of oxidative stress and inflammatory factors.Results: Although a significant within-group decrease in plasma protein carbonyl levels was seen in the probiotic capsule group (326.0 ± 308.9 vs. 251.0 ± 176.3 ng/mL, P = 0.02), the changes were similar among the three groups. In addition, significant within-group decreases in plasma iso prostaglandin were observed in the probiotic supplements group (111.9 ± 85.4 vs. 88.0 ± 71.0 pg/ mL, P = 0.003) and in the probiotic yogurt group (116.3 ± 93.0 vs. 92.0 ± 66.0 pg/mL, P = 0.02), nevertheless there were no significant change among the three groups.Conclusions: Taken together, consumption of probiotic yogurt or multispecies probiotic capsule had beneficial effects on biomarkers of oxidative stress in petrochemical workersKeywords: Iso prostaglandin, oxidative stress, petrochemical workers, probiotics, protein carbonylhttp://ijpm.mui.ac.ir/index.php/ijpm/article/view/1575http://ijpm.mui.ac.ir/index.php/ijpm/article/download/1575/1863