International Journal of Preventive Medicine (Int J Prev Med)2008-7802132015100615881588ENFood Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University Medical Sciences, IsfahanEndocrine and Metabolism Research Center, Isfahan University Medical Sciences, IsfahanFood Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University Medical Sciences, IsfahanFood Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University Medical Sciences, Isfahan20151006<p><strong>Background:</strong> This study was designed to examine the effects of purslane seeds on biomarkers of oxidative stress in type 2 diabetic patients.</p><p><strong>Methods:</strong> This cross‑over randomized controlled clinical trial was conducted on 40 patients with type 2 diabetes. Participants were randomly assigned to receive either 10 g/day purslane seeds with 240 cc low‑fat yogurt (intervention group) or only 240 cc low‑fat yogurt (as a control group) for 5 weeks. After a 2‑week washout period, subjects were moved to the alternate arm for an additional 5 weeks. At baseline and end of each study phase, fasting blood samples were collected to quantify biomarkers of oxidative stress.</p><p><strong>Results: </strong>We observed a slight decrease in plasma total antioxidant capacity in both groups, however, between‑group changes were not significant (&minus;2.67 vs. &minus;2.95 &micro;g/dL, P = 0.94). Plasma malondialdehyde in purslane group increased slightly, however, we observed no significant effect in the control group (1.62 vs. &minus;0.47 &micro;g/dL, P = 0.58). Although both groups had a slight reduction in plasma oxidized low‑density lipoprotein (ox‑LDL), we failed to find any significant effect of purslane on plasma ox‑LDL (&minus;1.06 vs. &minus;1.71 &micro;g/dL, P = 0.85).</p><p><strong>Conclusions:</strong> This cross‑over clinical trial revealed that consumption of purslane seeds for 5 weeks in type 2 diabetic patients did not result in improved oxidative stress.</p><p><strong>Keywords:</strong> Diabetes, medicinal plant, oxidative stress, purslane</p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/1588http://ijpm.mui.ac.ir/index.php/ijpm/article/download/1588/1878