International Journal of Preventive Medicine (Int J Prev Med)2008-7802142015110816031603ENDepartment of Periodontology, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed University, Karad, MaharashtraDepartment of Periodontology, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed University, Karad, MaharashtraDepartment of Orthodontics, Maratha Mandal Dental College, Belgaum, KarnatakaDepartment of Periodontology, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed University, Karad, MaharashtraDepartment of Prosthodontics, A.C.P.M. Dental College, Dhule, Maharashtra,20151108<p>Periodontitis is a disease of the periodontium, characterized by loss of connective tissue attachment and supporting the alveolar bone. Therefore, to regenerate these lost tissues of the periodontium researchers have included a variety of surgical procedures including grafting materials growth factors and the use of barrier membranes, ultimately resulting into regeneration that is biologically possible but clinically unpredictable. Recently a newer approach of delivering DNA plasmids as therapeutic agents is gaining special attention and is called gene delivery method. Gene therapy being considered a novel approach have a potential to channel their signals in a very systematic and controlled manner thereby providing encoded proteins at all stages of tissue regeneration. The aim of this review was to enlighten a view on the application involving gene delivery and tissue engineering in periodontal regeneration.</p><p><strong>Keywords:</strong> Gene, growth factors, periodontal regeneration, stem cells, tissue engineering, vectors</p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/1603http://ijpm.mui.ac.ir/index.php/ijpm/article/download/1603/1893