International Journal of Preventive Medicine (Int J Prev Med)2008-7802002016102917431743ENDepartment of Dermatology, Skin Diseases and Leishmaniasis Research Center, Medical School, Isfahan University of Medical Sciences, IsfahanDepartment of Dermatology, Skin Diseases and Leishmaniasis Research Center, Medical School, Isfahan University of Medical Sciences, IsfahanDepartment of Dermatology, Skin Diseases and Leishmaniasis Research Center, Medical School, Isfahan University of Medical Sciences, IsfahanSkin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran20161029<p>Acquired bilateral longitudinal true leukonychia is a rare disorder. We present a case of a 35‑year‑old healthy woman presented with this unusual and rare manifestation. She mentioned<br />a history of unprotected exposure to detergents and bleaching chemical agents. Considering her low zinc level, she was prescribed with zinc capsules and recommended to avoid chemical substances for 6 months. During bimonthly follow‑up, her zinc level turned normal, and leukonychia subsequently disappeared. Bilateral longitudinal true leukonychia in the nails due to zinc deficiency and exposure to chemical substances has not been reported previously. Direct and indirect effects of chemical substances on matrix and the effect of zinc deficiency on healing process should be considered in these cases.</p><p><strong>Keywords:</strong> Chemical agent, irritant contact dermatitis, true leukonychia, zinc deficiency</p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/1743http://ijpm.mui.ac.ir/index.php/ijpm/article/download/1743/2033