International Journal of Preventive Medicine (Int J Prev Med)2008-7802112017061018001800ENDepartment of Microbiology, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, SariStudent Research Committee, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, SariHealth Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, SariDepartment of Community Medicine, Zabol University of Medical Sciences, ZabolHealth Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari20170610<p><span class="fontstyle0">Human papillomavirus (HPV) can induce cervical intraepithelial neoplasia (CIN). Vaccination against HPV can play an important role in CIN prevention. This study aims to estimate the effcacy of L1 protein vaccines (Cervarix and Gardasil) in CIN 1, 2, 3 risk reduction using meta‑analysis. Relevant articles were identifed by two independent researchers searching international databanks. After application of inclusion/exclusion criteria and quality assessment, eligible articles were entered into the fnal meta‑analysis. Inverse variance method and fxed effect model were used to combine the results of the primary studies. The heterogeneity between the results was assessed using Cochrane and </span><span class="fontstyle2">I</span><span class="fontstyle0" style="font-size: 5pt;">2 </span><span class="fontstyle0">indices. Of 11,530 evidence identifed during the primary search, three papers were found<br />eligible for meta‑analysis, including 7213 participants in the intervention groups and 7170 healthy controls. The effcacy (95% confdence interval) of HPV 6, 11, 16, 18 monovalent and quadrivalent vaccines against CIN 1, CIN 2, and CIN 3 were estimated as of 95% (88&ndash;98), 97% (85&ndash;99), and<br />95% (78&ndash;99), respectively. This study showed that L1 protein vaccines Cervarix and Gardasil are highly protective vaccines playing an effective role in the prevention of HPV 6, 11, 16, 18 which are responsible for CIN 1, CIN 2, and CIN 3.</span></p><p><span class="fontstyle3"><strong>Keywords</strong>: </span><span class="fontstyle2">Cervical intraepithelial neoplasia, effcacy, human papillomavirus, meta‑analysis, vaccine</span> <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" /></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/1800http://ijpm.mui.ac.ir/index.php/ijpm/article/download/1800/2085