International Journal of Preventive Medicine (Int J Prev Med)2008-7802132017080918121812ENDepartment of Exercise Physiology, Physical Education and Sport Sciences Faculty, Hamedan University, HamedanDepartment of Exercise Physiology, Physical Education and Sport Sciences Faculty, Hamedan University, HamedanDepartment of Endocrine and Metabolism, Medicine Faculty, Isfahan University of Medical Sciences, IsfahanDepartment of Exercise Physiology, Physical Education and Sport Sciences Faculty, Hamedan University, Hamedan20170809<p><strong><span class="fontstyle0">Background: </span></strong><span class="fontstyle2">The purpose of this study was to investigate the effects of an 8‑week aerobic exercise and supplementation of 25(OH)D3 on GLP1 and DDP4 levels in men with type II diabetes.<br /></span></p><p><strong><span class="fontstyle0">Methods</span></strong><span class="fontstyle2"><strong>:</strong> In this semiexperimental research, among 40&ndash;60‑year‑old men with type II diabetes who were referred to the diabetic center of Isabn‑E Maryam hospital in Isfahan; of whom, 48 patients were voluntarily accepted and then were randomly divided into 4 groups: aerobic exercise group, aerobic exercise with 25(OH) D supplement group, 25(OH) D supplement group, and the control group. An aerobic exercise program was conducted for 8 weeks (3 sessions/week, each session 60 to75 min with 60&ndash;80% HRmax). The supplement user group received 50,000 units of oral Vitamin D once weekly for 8 weeks. The GLP1, DPP4, and 25(OH) D levels were measured before and after the intervention. At last, the data were statistically analyzed using the ANCOVA and </span><span class="fontstyle3">post hoc </span><span class="fontstyle2">test of least signifcant difference. </span></p><p><strong><span class="fontstyle0">Results: </span></strong><span class="fontstyle2">The results of ANCOVA showed a signifcant difference between the GLP1 and DPP4 levels in aerobic exercise with control group while these changes were not statistically signifcant between the 25(OH) D supplement group with control group (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.05).</span></p><p><strong><span class="fontstyle0">Conclusions: </span></strong><span class="fontstyle2">Aerobic exercises have resulted an increase in GLP1 level and a decrease in DPP4 level. However, consumption of Vitamin D supplement alone did not cause any changes in GLP1and DPP4 levels but led to an increase in 25‑hydroxy Vitamin D level.</span></p><p><strong><span class="fontstyle0" style="color: #00652e;">Keywords: </span></strong><span class="fontstyle3">Aerobic exercises, insulin resistance, mellitus diabetes, Vitamin D</span> <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" /></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/1812http://ijpm.mui.ac.ir/index.php/ijpm/article/download/1812/2101