International Journal of Preventive Medicine (Int J Prev Med)2008-7802932018040719041904ENDepartment of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non‑communicable Disease, Isfahan University of Medical Sciences, IsfahanNon‑communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj & Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, TehranDepartment of Pediatrics, Division of Nephrology, Rush University Medical Center, Chicago, IllinoisDepartment of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, AhvazDevelopment of Research Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, TehranDepartment of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non‑communicable Disease, Isfahan University of Medical Sciences, IsfahanDepartment of Health, Bureau of Health and Fitness, Ministry of Education and Training, TehranDepartment of Epidemiology, Offce of Adolescents and School Health, Ministry of Health and Medical Education, TehranChronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, TehranDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, TehranDepartment of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non‑communicable Disease, Isfahan University of Medical Sciences, IsfahanDepartment of Epidemiology, Office of Adolescents and School Health, Ministry of Health and Medical Education, TehranHealth Management and Economics Research Center, Iran University of Medical Sciences, TehranChronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran20180407<p><span class="fontstyle0"><strong>Background</strong>: </span><span class="fontstyle2">The prevalence of glomerular hyperfltration and chronic kidney disease is increasing worldwide in parallel with obesity hypertension epidemic. The effect of increases in glomerular<br />fltrations (GFR) in children with metabolic syndrome has not been studied. The purpose of the present study is to investigate the relationship between GFR and cardiometabolic risk factors in<br />a large sample of pediatric population. </span></p><p><strong></strong><span class="fontstyle0"><strong>Methods</strong>: </span><span class="fontstyle2">In this nationwide survey, 3800 participants were selected by cluster random sampling from 30 provinces in Iran. Anthropometric measures, biochemical, and clinical parameters were measured. We also measured estimated GFR (eGFR) using the recently modifed Schwartz equations and other known cardiometabolic risk factors such as elevated total cholesterol, high low‑density lipoprotein cholesterol (LDL‑C), and obesity.</span></p><p><strong></strong><span class="fontstyle0"><strong>Results</strong>: </span><span class="fontstyle2">The response rate was 91.5% (</span><span class="fontstyle3">n </span><span class="fontstyle2">= 3843). The mean and standard deviation (SD) (Mean ± SD) of eGFR for girls, boys, and total population were 96.71 ± 19.46, 96.49 ± 21.69, and 96.59 ± 20 ml/min/1.73 m</span><span class="fontstyle2" style="font-size: 5pt;">2</span><span class="fontstyle2">, respectively. Overall, 38.7% of the participants<br />did not have any cardiometabolic risk factor. In multivariate models, the risk of elevated systolic blood pressure (BP) (odds ratio [OR]: 1.48; 95% confdence interval [CI]: 1.08–2.02), elevated diastolic BP (OR: 1.48; 95% CI: 1.08–2.02), elevated LDL‑C (OR: 1.35; 95% CI: 1.07–1.70), and obesity (OR: 1.70; 95%CI: 1.24–2.33) were signifcantly higher in participants with higher eGFR level than those with the lower level but not with low level of high‑density lipoprotein<br />cholesterol (OR: 0.72; 95% CI: 0.60–0.88). </span></p><p><strong></strong><span class="fontstyle0"><strong>Conclusions</strong>: </span><span class="fontstyle2">This study demonstrates an association between glomerular hyperfltration and obesity‑related hypertension in a large sample of the Iranian pediatric population, independently of other classical risk factors.<br /></span></p><p><span class="fontstyle0" style="color: #00652e;"><strong>Keywords</strong>: </span><span class="fontstyle3">Cardiometabolic risk factors, children and adolescents, estimated glomerular fltration rate</span> </p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/1904http://ijpm.mui.ac.ir/index.php/ijpm/article/download/1904/717717729