International Journal of Preventive Medicine (Int J Prev Med)2008-7802962018070719291929ENDepartments of Anatomical Sciences and Molecular Biology Isfahan University of Medical Sciences, IsfahanBehavioral Sciences Research Center, Isfahan University of Medical Sciences, IsfahanBehavioral Sciences Research Center, Isfahan University of Medical Sciences, IsfahanDepartment of Pharmacognosy, The School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, IsfahanBehavioral Sciences Research Center, Isfahan University of Medical Sciences, IsfahanDepartments of Anatomical Sciences Tabriz University of Medical Sciences, TabrizDepartment of Biostatistics, The school of Health, Isfahan University of Medical Sciences, IsfahanDepartment of Pathology, School of Medicine, Kerman University of Medical Sciences20180704<p><span class="fontstyle0"><strong>Background</strong>: </span><span class="fontstyle2">Dementia as a major cognitive neurological disorder is defned as impairment in one or more cognitive territories compared with the former level of performance. This disorder disrupts patient&rsquo;s independence, and the patient would need others aid in order of doing daily and complex activities. The aim of this study was to evaluate the effcacy of Rosa damascena extract in the improvement of cognitive function in patients with dementia. </span></p><p><span class="fontstyle0"><strong>Methods</strong>: </span><span class="fontstyle2">This study is a randomized double-blind, placebo-controlled clinical trial on 40 patients older than 55 years with dementia referred to Specialized Elderly Patients Clinic in 2015&ndash;2016. Patients were divided randomly into two groups (control and intervention). The intervention group used donepezil and </span><span class="fontstyle3">R. damascena </span><span class="fontstyle2">capsules, and in control group, placebo capsule instead of </span><span class="fontstyle3">R. damascena </span><span class="fontstyle2">added on donepezil. Four test was flled three times at the study initiation, after month one and also after month three: Mini&ndash;Mental State Examination (MMSE) and Addenbrooke&rsquo;s Cognitive Examination Revised (ACE-R) were used for cognition evaluation, for depression assessment, Geriatric Depression Scale was administered,<br />and checklist of memory and behavioral disorders were flled. </span></p><p><span class="fontstyle0"><strong>Results</strong>: </span><span class="fontstyle2">The results showed add-on donepezil and </span><span class="fontstyle3">R. damascena </span><span class="fontstyle2">versus placebo improved cognitive impairment based on MMSE with </span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.002, ACE-R with total </span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.001, depression (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.012), behavioral disorders (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.001), and daily activity (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.001). </span></p><p><span class="fontstyle0"><strong>Conclusions</strong>: </span><span class="fontstyle2">The </span><span class="fontstyle3">R. damascena </span><span class="fontstyle2">extract affected cognitive impairment<br />of dementia patients signifcantly and also have signifcant effects on improving depression and behavioral problems.<br /></span></p><p><span class="fontstyle0" style="color: #00652e;"><strong>Keywords</strong>: </span><span class="fontstyle3">Dementia, neurocognitive disorders, Rosa damascena</span> <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" /></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/1929http://ijpm.mui.ac.ir/index.php/ijpm/article/download/1929/717717752