International Journal of Preventive Medicine (Int J Prev Med)2008-78021012019012320087802ENDepartment Federico II ENT, Menicagli Roberto Roma Biomed Research Lab, Marotta Ortensio University, NaplesDepartment Federico II ENT, Menicagli Roberto Roma Biomed Research Lab, Marotta Ortensio University, Naples20190123<p><span class="fontstyle0"><strong>Background</strong>: </span><span class="fontstyle2">Diabetes has a genetic predisposition and is generally not diagnosed for many years because hyperglycemia develops gradually, without presenting the classic symptoms of diabetes. The aim of this study is to verify whether, in a potentially genetically predisposed population,<br />men and women under the age of 50 years, at the time of the study, not suffering from diabetes can be detected using parameters derived from initial metabolic alteration indices of the possible evolution of pathology. </span></p><p><span class="fontstyle0"><strong>Methods</strong>: </span><span class="fontstyle2">In the hereditary and healthy group, salivary concentration of<br />malondialdehyde, total mucins, and pH were determined. All participants in the two groups had fasting glucose level below 110 mg/dL. The results were statistically analyzed using Pearson correlation test, Mann–Whitney test, and –Student’s </span><span class="fontstyle3">t</span><span class="fontstyle2">‑test. </span></p><p><strong></strong><span class="fontstyle0"><strong>Results</strong>: </span><span class="fontstyle2">Salivary concentration of malondialdehyde statistically increased in the hereditary group vs the healthy group (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.0368) as the mucins (</span><span class="fontstyle3">P </span><span class="fontstyle2">≤ 0.005). The salivary pH decreased but, the values were not statistically signifcant (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.085). Some alteration processes occur without increase in glucose levels, produced by changes in metabolic redox processes along with an increase in the salivary malondialdehyde index of oxidative stress in the body. The modifcation of the salivary buffer system lowers the pH, whereas increase in salivary mucins alters the value of spinnbarkeit, which measures the capacity of the mucous layer to adhere to the epithelium, causing alterations of the oral mucosa.<br /></span></p><p><span class="fontstyle0"><strong>Conclusions</strong>: </span><span class="fontstyle2">This study shows that it is possible to predict in hereditary predisposition conditions the development of diabetes, and the related dangerous consequences by monitoring two salivary<br />parameters – mucins and malondialdehyde.<br /></span></p><p><span class="fontstyle0" style="color: #00652e;"><strong>Keywords</strong>: </span><span class="fontstyle3">Diabetes, genetic predisposition, mucins free radicals</span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/1998http://ijpm.mui.ac.ir/index.php/ijpm/article/download/1998/717717818