International Journal of Preventive Medicine (Int J Prev Med)2008-78021012019012320087802ENDepartment of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, IsfahanDepartment of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, IsfahanDepartment of Internal Medicine, Kashan University of Medical Sciences, KashanIsfahan Endocrine and Metabolism Research Center & Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, IsfahanResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan20190123<p><span class="fontstyle0"><strong>Background</strong>: </span><span class="fontstyle2">The aim of the study was to determine the effects of coenzyme Q10 (CoQ10) supplementation on biomarkers of inflammation and oxidative stress among diabetic hemodialysis (HD) patients. </span></p><p><span class="fontstyle0"><strong>Methods</strong>: </span><span class="fontstyle2">Sixty diabetic HD patients participated in the randomized, double blind, placebo-controlled clinical trial. They were randomly assigned into two groups to intake either 60 mg CoQ10 supplements (</span><span class="fontstyle3">n </span><span class="fontstyle2">= 30) or placebo (</span><span class="fontstyle3">n </span><span class="fontstyle2">= 30) twice a day for 12 weeks.</span></p><p><strong></strong><span class="fontstyle0"><strong>Results</strong>: </span><span class="fontstyle2">After 12 weeks of intervention, CoQ10 supplementation signifcantly increased total antioxidant (TAC) (54.921 ± 26.437 vs. -126.781 ± 26.437, </span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.001) and nitric oxide (NO) levels (4.121 ± 1.314 vs. -1.427 ± 1.314, </span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.006) and decreased C-reactive protein (CRP) (-1.302 ± 0.583 vs. 0.345 ± 0.583, 0.042) levels compared with the placebo. We did not observe any signifcant effect of CoQ10 supplementation on malondialdehyde (MDA) and glutathione (GSH) levels compared with the placebo. </span></p><p><span class="fontstyle0"><strong>Conclusions</strong>: </span><span class="fontstyle2">Overall, our study showed that CoQ10 supplementation to diabetic HD patients for 12 weeks was associated with increased levels of TAC and NO levels and decreased level of high-sensitivity CRP (hs-CRP) levels, but did not have<br />any benefcial effects on MDA and GSH.<br /></span></p><p><span class="fontstyle0" style="color: #00652e;"><strong>Keywords</strong>: </span><span class="fontstyle3">Coenzyme Q10 supplementation, hemodialysis, inflammatory markers, oxidative stress</span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/1999http://ijpm.mui.ac.ir/index.php/ijpm/article/download/1999/717717819