International Journal of Preventive Medicine (Int J Prev Med)2008-78021012019012320087802ENDepartment of Basic Medical Sciences, Neyshabur University of Medical Sciences, NeyshaburStudent Research Committee, Neyshabur University of Medical Sciences, Neyshabur,20190123<p><span class="fontstyle0">New evidence suggests that low serum Vitamin D may cause nonalcoholic fatty liver disease (NAFLD). Hypovitaminosis D is associated with the severity and incidence of NAFLD. The objective of this study was to conduct a systematic review on randomized controlled trials (RCTs) assessing the effect of Vitamin D on serum metabolic profle among NAFLD patients. Databases including PubMed, Institute for Scientifc Information Web of Science, Scopus, and Google Scholar were searched up to November 2016. RCTs which studied Vitamin D effect on metabolic profles and liver function, and conducted among adults were included. Six articles were eligible<br />to be considered in this systematic review. According to the result, Vitamin D supplementation might improve lipid profle and inflammatory mediators when compared with placebo. No article indicated signifcant effect of Vitamin D on liver enzymes except one article which revealed that<br />Vitamin D together with calcium carbonate can reduce liver enzymes. Vitamin D supplementation may not improve anthropometric measures and glycemic index variables among patients with NAFLD. Vitamin D supplement might improve NAFLD symptoms, especially inflammatory<br />mediators. More RCTs in different parts of world with different forms and doses of Vitamin D are necessary.<br /></span></p><p><span class="fontstyle2"><strong>Keywords</strong>: </span><span class="fontstyle3">Nonalcoholic fatty liver disease, systematic review, Vitamin D</span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2001http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2001/717717821