International Journal of Preventive Medicine (Int J Prev Med)2008-78021022019021920087802ENDepartment of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, IsfahanDepartment of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, IsfahanDepartment of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, IsfahanDepartment of Epidemiology and Biostatistics, School of Health, Shahrekord University of Medical Sciences, ShahrekordInternal Center, Imam Ali Hospital of Farokhshahr, Social Security Organization, Shahrekord20190218<p><span class="fontstyle0"><strong>Background</strong>: </span><span class="fontstyle2">Vitamin D plays an important role in nervous health and depression. Vitamin D<br />defciency and anxiety affect diabetic status. The purpose of this study was to determine the effect of<br />vitamin D supplementation on anxiety, depression, and inflammation in diabetic women with anxiety.<br /></span><span class="fontstyle0"><strong>Methods</strong>: </span><span class="fontstyle2"> In this randomized controlled trial, totally 51  women with type 2 diabetes (T2DM)<br />and vitamin D defciency were randomly allocated to receive one oral pearl of 50,000 IU vitamin<br />D3 (26 women) or a placebo (25 women) fortnightly for 16 weeks. Anthropometric indices, sun<br />exposure, dietary intake, depression, anxiety, and stress scores and biochemical biomarkers including<br />high sensitivity C‑reactive protein (hs‑CRP) and interleukin‑10 (IL‑10) were measured at the baseline<br />and after 16‑week supplementation. </span></p><p><span class="fontstyle0"><strong>Results</strong>: </span><span class="fontstyle2">Mean ± SD age of participant was 47.43 ± 9.57 years<br />old. Baseline values were  not different between the groups. Anxiety score changes were signifcantly<br />lower in vitamin D group than the controls (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.001). Within group comparison indicated that<br />depression in supplement group with lower vitamin D levels was signifcantly reduced. Serum<br />hs‑CRP reduced (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.01), while IL‑10 concentrations increased (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.04) in the intervention<br />group. </span></p><p><span class="fontstyle0"><strong>Conclusions</strong>: </span><span class="fontstyle2">Vitamin D supplementation can improve mood status and anti‑inflammatory<br />biomarkers in female diabetics with anxiety and vitamin D defciency.<br /></span></p><p><span class="fontstyle0" style="color: #00652e;"><strong>Keywords</strong>: </span><span class="fontstyle3">Anxiety, diabetes, inflammation, Vitamin D, women</span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2004http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2004/717717825