International Journal of Preventive Medicine (Int J Prev Med)2008-78021032019031820087802ENDepartment of Sport Physiology, Shahid Chamran University of Ahvaz, Ahvaz & Department of Sport Physiology, Tarbiat Modares University, TehranDepartment of Sport Physiology, Shahid Chamran University of Ahvaz, AhvazSchool of Science and Sport, University of the West of Scotland, PaisleyDepartment of Sport Physiology, Shahid Chamran University of Ahvaz, AhvazDepartment of Sport Physiology, Shahid Chamran University of Ahvaz, Ahvaz & Department of Sport Physiology, Tarbiat Modares University, TehranDepartment of Radiology, Jundishapur University of Medical Sciences, AhvazInstitute of Sports Sciences and Innovation, Lithuanian Sports University, Kaunas20190318<p><span class="fontstyle0"><strong>Background</strong>: </span><span class="fontstyle2">Sarcopenia describes the inevitable deterioration in muscle mass and strength that accompanies biological aging. The purpose of this study was to investigate the effects of resistance training (RT) on quadriceps hypertrophy and related biochemistry in sarcopenic and healthy elderly men. </span></p><p><span class="fontstyle0">Methods</span><span class="fontstyle2">: A total of 31 elderly men (55–70 years old) were classifed as sarcopenic and nonsarcopenic and were divided into two groups. Both groups participated in a progressive RT program for 8 weeks. </span></p><p><span class="fontstyle0"><strong>Results</strong>: </span><span class="fontstyle2">Data indicated that the strength in the sarcopenic group increased<br />more than the healthy group (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.05). Quadriceps cross‑sectional area also increased more in the healthy group (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.05). Myostatin concentration decreased in both groups after training (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.05).<br />Follistatin and testosterone increased in the healthy group; in contrast, only testosterone increased in the sarcopenic group after training (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.05). </span></p><p><span class="fontstyle0"><strong>Conclusions</strong>: </span><span class="fontstyle2">The fndings from this study suggest that RT improves muscle cross‑sectional area and biomarker‑related muscle loss in both healthy and<br />sarcopenic elderly men. The fndings also demonstrate that growth factor profles at baseline and changes in testosterone levels play an important role in muscle hypertrophy observed in both groups.<br /></span></p><p><span class="fontstyle0" style="color: #00652e;"><strong>Keywords</strong>: </span><span class="fontstyle3">Aging, follistatin, hypertrophy, myostatin, resistance training, sarcopenia</span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2017http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2017/717717837