Protective Role of Angiotensin Type 1 Receptor Blockade in 4/6 Nephrectomized Male and Female Rats

International Journal of Preventive Medicine (Int J Prev Med)2008-780210520190529Protective Role of Angiotensin Type 1 Receptor Blockade in 4/6 Nephrectomized Male and Female Rats20492049ENWater and Electrolytes Research Center, Isfahan University of Medical Sciences, IsfahanWater and Electrolytes Research Center, Isfahan University of Medical Sciences, IsfahanWater and Electrolytes Research Center & Department of Physiology, Isfahan University of Medical Sciences & Isfahan MN Institute of Basic and Applied Sciences Research, Isfahan20190526Background: Chronic kidney disease associated with serious morbidity and mortality rate while it is affected by renin‑angiotensin system. The effects of losartan as angiotensin II Type 1 receptor antagonist on renal functional in 4/6 nephrectomized rats was evaluated. Methods: Twenty‑six male and female Wistar rats underwent 4/6 nephrectomy, and the animals from each gender were randomly divided into two groups which treated with vehicle and losartan (10 mg/kg/day for 1 week). The parameters related to kidney function were measured. Results: Creatinine (Cr) clearance and urine ﬂow were improved in losartan‑treated group signifcantly (P < 0.05). The serum level of blood urea nitrogen and Cr and kidney tissue damage score and sodium urinary output (UNaV) did not alter. However, losartan decreased percentage of sodium excretion (ENa %) in both genders insignifcantly. Conclusions: Losartan may improve renal function in 4/6 nephrectomized male rats. Keywords: Losartan, nephrectomy, rathttp://ijpm.mui.ac.ir/index.php/ijpm/article/view/2049http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2049/717717867