International Journal of Preventive Medicine (Int J Prev Med)2008-78021052019060120562056ENDepartment of Physiology, Water and Electrolytes Research Center, Isfahan University of Medical Sciences, IsfahanDepartment of Physiology, Water and Electrolytes Research Center, Isfahan University of Medical Sciences, IsfahanDepartment of Physiology, Water and Electrolytes Research Center & Department of Physiology, Isfahan University of Medical Sciences & Isfahan MN Institute of Basic and Applied Sciences Research, Isfahan20190601<p><span class="fontstyle0"><strong>Background</strong>: </span><span class="fontstyle2">Zinc (Zn) knows as essential microelement which prevents oxidative stress. The effect of Zn supplement on renal function parameters in rats subjected to renal ischemia‑reperfusion (IR) injury was investigated. </span></p><p><strong></strong><span class="fontstyle0"><strong>Methods</strong>: </span><span class="fontstyle2">Male and female rats were subjected to renal IR with and without Zn sulfate (10 mg/kg/day for 5 days) supplementation. The kidney function markers and histology fndings in Zn‑treated group were compared with sham and control groups. </span></p><p><span class="fontstyle0"><strong>Results</strong>: </span><span class="fontstyle2">The serum levels of blood urea nitrogen and creatinine (Cr) and kidney tissue damage score were increased signifcantly after renal injury (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.05) gender dependently, but no alterations were observed for these markers in Zn‑treated animals after renal IR injury. Cr clearance was signifcantly different<br />between genders (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.05); however, Zn supplementation increased the Cr clearance and kidney nitrite level signifcantly in male rats (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.05). Zn also increased urine flow in female (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.05), but it did not alter urine load of Na (U</span><span class="fontstyle2" style="font-size: 5pt;">Na</span><span class="fontstyle2">V) and percentage of Na excretion (E</span><span class="fontstyle2" style="font-size: 5pt;">Na</span><span class="fontstyle2">%). </span></p><p><strong></strong><span class="fontstyle0"><strong>Conclusions</strong>: </span><span class="fontstyle2">Zn may improve renal function after IR injury gender dependently.<br /></span></p><p><span class="fontstyle0" style="color: #00652e;"><strong>Keywords</strong>: </span><span class="fontstyle3">Gender, rats, renal ischemia‑reperfusion, zinc</span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2056http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2056/717717874