International Journal of Preventive Medicine (Int J Prev Med)2008-78021082019092821222122ENDepartment of Preventive Oncology, Tata Memorial Hospital, Mumbai, MaharashtraDepartment of Preventive Oncology, Tata Memorial Hospital, Mumbai, MaharashtraDepartment of Preventive Oncology, Tata Memorial Hospital, Mumbai, Maharashtra20190904<p><span><strong>Background: </strong><span>The objective of the study is to comparatively evaluate performance of human <span>papillomavirus (HPV) hybrid capture 2 (HC2) and cytology as triage tests among visual inspection <span>after application of 3–5% acetic acid (VIA) screen positive women, thus aiming to reduce the referral<br /><span>burden. </span></span></span></span></span></p><p><span><span><span><span><span><span><strong>Methods: </strong><span>The community-based cross sectional cervical cancer screening with VIA was <span>conducted among women aged between 30 and 65, residing in selected low socio-economic areas <span>of Mumbai, India, during October 2010–March 2017. After obtaining informed consent, delivering <span>health education and collecting socio-demographic data, participants were offered VIA screening <span>by trained primary health workers. The VIA screen positive women underwent cytology, HPV HC2 <span>and diagnostic colposcopy at nodal hospital. Women with positive colposcopy underwent cervical <span>biopsies. </span></span></span></span></span></span></span></span></span></span></span></span></span></p><p><span><span><span><span><span><span><span><span><span><span><span><span><span><span><strong>Results: </strong><span>231 VIA positive women underwent cytology and HPV HC2 test, followed by <span>colposcopy. Cervical biopsies were obtained in 83 cases. The sensitivity and specificity in detecting <span>≥ CIN 2 were 77.8 and 92.3 for HC2 and 66.7 and 98.2 for cytology. The false positivity and <span>negativity rates were 7.7 and 22.2 for HC2 and 1.8 and 33.3 for cytology. </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p><p><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><strong>Conclusions: </strong><span>HPV HC2 <span>reduces referrals to larger extent and misses fewer cases compared to cytology, thus appearing a <span>better triage test among VIA positive women.<br /></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p><p><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><strong>Keywords: </strong><span><em>Cell biology, human papillomavirus DNA tests, mass screening, triage</em></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><br /></span></span></span></span></span></span></span></span></span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2122http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2122/717717984