International Journal of Preventive Medicine (Int J Prev Med)2008-78021082019092821232123ENDepartment of Periodontics, School of Dentistry, Isfahan (Khorasgan) Branch, Isalmic Azad University, IsfahanGeneral Dentist, IsfahanGeneral Dentist, Isfahan20190904<p><span><strong>Background: </strong><span>Periimplant diseases are inflammatory diseases. Thus, the level of preinflammatory <span>cytokines which has important role in the inflammation processes can consider as biomchemical <span>markers for early diagnosis and prevention of periimplant diseases. The aim of this study was to <span>determine and compare the level of interleukin (IL)‑17 and IL‑10 in patients with periimplant mucositis <span>and periimplantitis. </span></span></span></span></span></span></p><p><span><span><span><span><span><span><span><strong>Methods: </strong><span>This case‑‑control study was conducted on 51 patients with implants<br /><span>which were loaded at least 1 year previously, 17 patients with periimplant mucositis, 17 patients with <span>periimplantitis, and 17 individuals with healthy implants. After clinical examination, gingival crevicular <span>fluid sampling was carried out by paper point number 25 for 4 min and the mean value of IL‑17, IL‑10 <span>in samples was measured using enzyme linked immunosorbent assay (ELISA), least square differences <span>(LSD) reader in laboratory. The data was analyzed using statistical software SPSS 22. Quantitative <span>analysis was done using One‑way analysis of variance (ANOVA) test and LSD past  test. </span></span></span></span></span></span></span></span></span></span></span></span></span></span></p><p><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><strong>Results: </strong><span>The <span>results of analysis showed that there was a significant difference in the mean value of IL‑17 and IL‑10 <span>between the three study groups (<span><em>P </em><span>&lt; 0.001). Individuals with healthy implants showed a significant <span>lower level of IL‑17 than patients with periimplantitis (<span><em>P </em><span>= 0.001) and for patients with periimplantitis,<br /><span>the level of IL‑17 was significantly lower than that of patients with periimplant mucositis (<span><em>P </em><span>&lt; 0.001) <span>and IL‑10 level was significantly lower in mucositis than periimplantitis (<span><em>P </em><span>&lt; 0.001). </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p><p><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><strong>Conclusions: </strong><span>The <span>level of IL‑17 and IL‑10 increased in patients with periimplant compared to individuals with healthy <span>periimplant tissues and the results showed that the highest concentrations of IL‑17 and IL‑10 were <span>observed in patients with periimplant mucositis and periimplantitis, respectively.<br /></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p><p><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><strong>Keywords: </strong><span><em>Interleukin‑10, interleukin‑17, mucositis, periimplantitis</em></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><br /></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2123http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2123/717717985