International Journal of Preventive Medicine (Int J Prev Med)2008-780210102020020921522152ENYemen Ministry of Health, Yemen Field Epidemiology, Tareem City & Hadramout Valley and Desert Oncology Center, Seiyun City, HadramoutHadramout Valley and Desert Oncology Center, Seiyun City, HadramoutHadramout Valley and Desert Oncology Center, Seiyun City, HadramoutHadramout Valley and Desert Oncology Center, Seiyun City, HadramoutDepartment of Community Medicine, Public Health and Family Medicine, Jordan University of Science and Technology, Irbid20200119<p><span class="fontstyle0"><strong>Background</strong>: </span><span class="fontstyle2">The incidence of breast cancer is on rise in low‑ and middle‑income countries as populations increasingly adopt western lifestyles. Studies on risk factors of cancers including breast cancer are lacking in Yemen. Therefore, this study aimed to determine the risk factors of breast cancer among women registered at Hadramout Valley and Desert Oncology Center (HVDOC). </span></p><p><strong></strong><span class="fontstyle0"><strong>Methods</strong>: </span><span class="fontstyle2">A case–control study was conducted at HVDOC, Yemen. All women who were registered in HVDOC and diagnosed with breast cancer and confirmed by histopathology during 2011– 2015 were selected as cases. Age‑matched controls were selected from women who underwent mammography in HVDOC during 2011–2015 and were confirmed to be free of breast cancer. Data were collected using semi‑structured questionnaire and clinical data were abstracted from the<br />medical records.</span></p><p><strong></strong><span class="fontstyle0"><strong>Results</strong>: </span><span class="fontstyle2">A total of 105 patients and 210 controls were included in this study. About<br />70.5% of cases and 72.4% of control were 50 years old or younger. Compared with married women, divorced women had higher odds of breast cancer [odds ratio (OR) = 2.2]. The odds of breast cancer was higher for women who had never breastfed a child (OR = 1.7). Having hypertension (OR = 2.5), family history of malignancy (OR = 2.4), and postmenopausal status (OR = 2.0) were significantly associated with higher odds of breast cancer in multivariate analysis. </span></p><p><span class="fontstyle0"><strong>Conclusions</strong>: </span><span class="fontstyle2">The main risk factors for breast cancer among women in Yemen are divorced marital status, never breastfed a child, having hypertension, family history of malignancy, and postmenopause. Regular screening especially among women with high risk is needed.<br /></span></p><p><span class="fontstyle0" style="color: #00652e;"><strong>Keywords</strong>: </span><span class="fontstyle3">Breast neoplasm, case–control study, risk factors, Yemen</span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2152http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2152/717717948