International Journal of Preventive Medicine (Int J Prev Med)2008-780210122020031521992199ENFood Security Research Center, Isfahan University of Medical Sciences, Isfahan & Food Safety Research Center (salt), Semnan University of Medical Sciences, SemnanFood Security Research Center, Isfahan University of Medical Sciences, Isfahan & Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, TehranDepartment of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, IsfahanDepartment of Gynecology, School of Medicine Science, Isfahan University of Medical Sciences, IsfahanFood Security Research Center, Isfahan University of Medical Sciences, Isfahan & Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran20200315<p><span class="fontstyle0"><strong>Background</strong>: </span><span class="fontstyle2">Body of evidence is increasing about the importance of Vitamin D (VD) for<br />normal development of the fetus and for maternal health. As limited data are available regarding<br />the association between maternal VD level and pregnancy‑related complications and neonatal<br />anthropometric measures, the present study aimed to evaluate the neonatal anthropometric measures<br />including weight, high, and head circumference and pregnancy‑related complications such as<br />preeclampsia, blood pressure, gestational diabetes mellitus, and nausea and vomiting in pregnancy with<br />25(OH)VD level. </span></p><p><span class="fontstyle0"><strong>Methods</strong>: </span><span class="fontstyle2">The current prospective observational study was conducted among 812<br />Iranian pregnant women during the first trimester in Isfahan, Iran. Needed data were collected using<br />validated questionnaires and biochemical examinations. </span></p><p><strong></strong><span class="fontstyle0"><strong>Results</strong>: </span><span class="fontstyle2">Overall, this study demonstrated<br />an inverse significant association between VD level and chance of having low‑weight infant in the<br />adjusted model (odds ratio [OR]: 0.03, 95% confidence interval [CI]: 0.004–0.26, </span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.001) in<br />the first VD assessment. The same results were obtained in the second VD assessment (OR: 0.08,<br />95% CI: 0.01–0.40, </span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.01). However, such associations were not seen about other neonatal<br />measures and pregnancy‑related complications. </span></p><p><span class="fontstyle0"><strong>Conclusions</strong>: </span><span class="fontstyle2">We found that low maternal VD level<br />might be associated with risk of low‑weight infant. Such findings could be considered to implement<br />informative interventional programs to control newborn adverse outcomes. Further studies are<br />required to confirm these findings.<br /></span></p><p><span class="fontstyle0" style="color: #00652e;"><strong>Keywords</strong>: </span><span class="fontstyle3">Maternal Vitamin D, neonatal anthropometric measures, pregnancy complications</span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2199http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2199/717717998