International Journal of Preventive Medicine (Int J Prev Med)2008-780210122020031522012201ENDepartment of Cardiology, Najafabad Branch, Islamic Azad University, NajafabadDepartment of Internal Medicine, Islamic Azad University, NajafabadDepartment of Cardiology, Najafabad Branch, Islamic Azad University, NajafabadClinical Anatomical Pathology, Dr. Fouladi Laboratory, Isfahan20200315<p><span class="fontstyle0"><strong>Background</strong>: </span><span class="fontstyle2">Despite many attempts to discover pathophysiologic mechanisms to explain chronic<br />heart failure (CHF), no conceptual paradigms have been proved yet. Various studies have shown<br />the role of trace elements on heart failure (HF). Among all trace elements, selenium deficiency<br />is regarded as important risk factors for HF. Considering selenium deficiency in our society and<br />high prevalence of HF, we compared selenium level in patients with HF with healthy individuals.<br /></span></p><p><span class="fontstyle0"><strong>Methods</strong>: </span><span class="fontstyle2">In all, 32 hospitalized patients with HF and 32 healthy controls were enrolled in a<br />case–control study. Demographic characteristics as well as functional class and risk factors were<br />recorded for all two groups. Echocardiography was conducted for patients and all provided data<br />were registered. Then serum selenium levels were compared in case and control groups. </span></p><p><span class="fontstyle0"><strong>Results</strong>: </span><span class="fontstyle2">The mean (±standard deviation) serum selenium was 92.5 ± 22.44 mg/dL in patients with HF and<br />109.3 ± 29.62 mg/dL in controls. The level of selenium was significantly lower and the frequency<br />of risk factors was significantly higher in case group. Selenium level did not differ significantly in<br />patients with different HF causes. There were a nonsignificant relationship between selenium level<br />and left ventricular ejection fraction and a significant reverse relationship between selenium level and<br />left ventricular volume and pulmonary artery pressure. </span></p><p><span class="fontstyle0"><strong>Conclusions</strong>: </span><span class="fontstyle2">Our results showed statistically<br />significant lower level of serum selenium in patients with CHF in comparison to normal individuals.<br />Moreover, selenium level had significant reverse relationship with left ventricular volume and<br />pulmonary artery pressure.<br /></span></p><p><span class="fontstyle0" style="color: #00652e;"><strong>Keywords</strong>: </span><span class="fontstyle3">Heart failure, left ventricular volume, selenium</span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2201http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2201/717718000