International Journal of Preventive Medicine (Int J Prev Med)2008-780210122020031522032203ENFood Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran,Department of Neurology, Isfahan University of Medical Sciences, IsfahanDepartment of Infectious Diseases, Isfahan University of Medical Sciences, IsfahanDepartment of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, IsfahanPediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non‑ communicable Disease and Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, IsfahanDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan20200315<p><span class="fontstyle0"><strong>Background</strong>: </span><span class="fontstyle2">Inflammation is defined as body tissues response to harmful stimuli. Obesity‑related<br />inflammation leads to increased risk chronic diseases including diabetic polyneuropathy (DPN).<br />The present study was performed to determine association between body mass index (BMI) and<br />inflammatory markers including erythrocyte sedimentation rate (ESR) and C‑reactive protein (CRP)<br />in DPN patients. </span></p><p><span class="fontstyle0"><strong>Methods</strong>: </span><span class="fontstyle2">In this cross‑sectional study, 200 DPN patients with a mean (SD) of age<br />58.76 (9.53) years were selected. All patients completed the questionnaire including demographic<br />data and chronic disease history. In addition, anthropometric measures and clinical laboratory tests<br />were taken. Multivariate linear regression was used to detect the association between BMI, CRP,<br />and ESR levels. </span></p><p><span class="fontstyle0"><strong>Results</strong>: </span><span class="fontstyle2">BMI was associated with increase in ESR and CRP levels (</span><span class="fontstyle3">β</span><span class="fontstyle2">‑ESR = 4.67,<br /></span><span class="fontstyle4">P </span><span class="fontstyle2">&lt; 0.001 and </span><span class="fontstyle3">β</span><span class="fontstyle2">‑CRP = 0.71, </span><span class="fontstyle4">P </span><span class="fontstyle2">&lt; 0.001). Also, this association remained after adjustment for other<br />different variables. </span></p><p><span class="fontstyle0"><strong>Conclusions</strong>: </span><span class="fontstyle2">These findings indicate that higher BMI is related to increase<br />inflammatory markers including CRP and ESR in DPN patients. Therapies for DPN and reducing<br />inflammation should target the weight loss among obese patients.<br /></span></p><p><span class="fontstyle0" style="color: #00652e;"><strong>Keywords</strong>: </span><span class="fontstyle4">Body mass index, C‑reactive protein, diabetes, erythrocyte sedimentation rate,<br />polyneuropathy</span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2203http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2203/717718002