International Journal of Preventive Medicine (Int J Prev Med)2008-780210122020031522092209ENDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, IsfahanDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, IsfahanDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, IsfahanDepartment of Epidemiology and Biostatistics, Isfahan Endocrine and Metabolism Research Center, School of Public Health, Isfahan University of Medical Sciences, IsfahanUniversity of Medical Sciences, Shiraz20200315<p><span class="fontstyle0"><strong>Background</strong>: </span><span class="fontstyle2">Hyperlipidemia and hypertension are the most important causes of ischemic<br />heart disease. There is evidence that flaxseed powder can improve lipid profile and blood<br />pressure. In this study, we want to investigate the effects of flaxseed powder consumption<br />on patients with hyperlipidemia and hypertension. </span></p><p><span class="fontstyle0"><strong>Methods</strong>: </span><span class="fontstyle2">This randomized double‑blind<br />placebo‑controlled clinical trial was performed on 80 hyperlipidemic and hypertensive patients<br />(men and women between 20 and 60 years old). In this study, participants were recruited from Imam<br />Khomeini hospital clinics of Shiraz University of Medical Sciences in 2017 randomly allocated<br />to flaxseed powder group and placebo group. The intervention group received 36 g of flaxseed<br />sachet (</span><span class="fontstyle3">n </span><span class="fontstyle2">= 40), and control group received 12 g placebo sachet (</span><span class="fontstyle3">n </span><span class="fontstyle2">= 40) for 8 weeks. Serum lipid<br />profiles, blood pressure, fasting blood sugar, and anthropometric indices were measured. Data were<br />analyzed by using SPSS.</span></p><p><strong></strong><span class="fontstyle0"><strong>Results</strong>: </span><span class="fontstyle2">We found significant reduction (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.001) in anthropometric<br />indices (waist circumference and waist‑to‑hip ratio) and lipid profiles (triglycerides [</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.015], total<br />cholesterol [</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.018], and low‑density lipoprotein [</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.001]) within flaxseed group in comparison<br />with placebo group. </span></p><p><strong></strong><span class="fontstyle0"><strong>Conclusions</strong>: </span><span class="fontstyle2">Based on beneficial effects of flaxseed on cardiovascular risk<br />factors, it seems that flaxseed consumption can be considered as a useful therapeutic approach for<br />reducing lipid profile and anthropometric indices.<br /></span></p><p><span class="fontstyle0" style="color: #00652e;"><strong>Keywords</strong>: </span><span class="fontstyle3">Cardiovascular diseases, flax, hyperlipidemias, hypertension</span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2209http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2209/717718008