International Journal of Preventive Medicine (Int J Prev Med)2008-780210122020031522102210ENDepartments of Cardiology, AJA University of Medical Sciences, TehranDepartments of Pediatric Nephrology, AJA University of Medical Sciences, TehranDepartment of Internal Medicine & Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, IsfahanDepartments of Cardiology, AJA University of Medical Sciences, TehranDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Sciences, IsfahanDepartments of Pediatric Nephrology, AJA University of Medical Sciences, Tehran20200315<p><span class="fontstyle0"><strong>Background</strong>: </span><span class="fontstyle2">Cardiovascular disease (CVD) is the most common cause of death among patients<br />with end‑stage renal disease especially whom under hemodialysis (HD). Stromal cell‑derived<br />factor‑1 (SDF‑1) and its receptor CXC chemokine receptor type‑4 (CXCR4) could contribute to<br />CVD. The main aim of this study was to evaluate the association between SDF‑1 and CXCR4 with<br />CVD and its related risk factors in patients under HD. </span></p><p><span class="fontstyle0"><strong>Methods</strong>: </span><span class="fontstyle2">Sixty patients under HD and 29<br />healthy subjects were recruited in the study. The serum levels and relative messenger RNA (mRNA)<br />expressions of SDF‑1 and CXCR4 were measured using enzyme‑linked immunosorbent assay and<br />real‑time polymerase chain reaction in patients and controls, respectively. CVD history of the patients<br />was obtained. </span></p><p><span class="fontstyle0"><strong>Results</strong>: </span><span class="fontstyle2">Twenty patients (33.3%) had a history of CVD. The mean levels of serum and<br />relative mRNA expressions of SDF‑1 and CXCR4 were higher in patients than controls and also in<br />patients with a history of CVD than patients without it. The serum levels and relative expressions of<br />SDF‑1 and CXCR4 were positively correlated with blood urea nitrogen, parathyroid hormone, and<br />high‑sensitivity C‑reactive protein and inversely correlated with hemoglobin. The history of CVD was<br />the independent predictor of serum levels of SDF‑1 and CXCR4 and also relative mRNA expression<br />of CXCR4. </span></p><p><strong></strong><span class="fontstyle0"><strong>Conclusions</strong>: </span><span class="fontstyle2">The higher levels of serum and relative mRNA expressions of SDF‑1 and<br />CXCR4 were associated with CVD in patients under HD. Furthermore, SDF‑1 and CXCR4 were<br />associated with several traditional and uremia‑related CVD risk factors in such patients.<br /></span></p><p><span class="fontstyle0" style="color: #00652e;"><strong>Keywords</strong>: </span><span class="fontstyle3">Cardiovascular disease, CXC chemokine receptor type 4, end‑stage renal disease, hemodialysis, stromal cell‑derived factor‑1</span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2210http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2210/717718009