International Journal of Preventive Medicine (Int J Prev Med)2008-78021122020042022302230ENIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, IsfahanIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, IsfahanIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, IsfahanIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, IsfahanDepartment of Neurology, School of Medical, Isfahan University of Medical Science, IsfahanDepartment of Neurology, Mazandaran University of Medical Sciences, SariDepartment of Emergency, Abadan University of Medical Science, Abadan20200420<p><span class="fontstyle0"><strong>Background</strong>: </span><span class="fontstyle2">Epilepsy is a chronic neurologic condition and affects people of all ages. Seizure<br />clusters are generally referred to seizures that occur at close intervals with complete recovery<br />between attacks. Various studies have reported a variety of frequencies and risk factors for this<br />condition. </span></p><p><span class="fontstyle0"><strong>Methods</strong>: </span><span class="fontstyle2">We designed a study to determine the frequency of seizure cluster and their<br />associated risk factors in Iranian population for the first time. </span></p><p><span class="fontstyle0"><strong>Results</strong>: </span><span class="fontstyle2">Among 40 variables analyzed,<br />18 of them were significantly associated with seizure clustering. Risk factors including educational<br />level, age of onset, number of drugs, seizure types, perinatal complication, developmental delay,<br />other illnesses, parental consanguinity, systemic diseases, number of drugs used, mentation, motor<br />signs, sensory signs, cranial nerves signs, cerebellar signs, seizure duration, existence of magnetic<br />resonance imaging (MRI) lesion, and type of MRI pathology are significantly associated with<br />clustering of seizures. When associated risk factors were analyzed with multivariate analysis, age<br />of onset of seizures, number of antiepileptic drugs currently used, lack of seizure‑free periods,<br />seizure frequency, and type of MRI pathology are significantly defining for anticipating clustering<br />of seizures. </span></p><p><span class="fontstyle0"><strong>Conclusions</strong>: </span><span class="fontstyle2">Seizure cluster has a significant negative impact on the quality of life<br />of patients. Important risk factors that are found to be associated are age of onset, parental<br />consanguinity, frequency of seizure, lack of have seizure‑free period or periods, pathologies in<br />neurological examination, and MRI findings.<br /></span></p><p><span class="fontstyle0" style="color: #00652e;"><strong>Keywords</strong>: </span><span class="fontstyle3">Epilepsy, predictors, risk factors, seizure freedom</span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2230http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2230/717718055