International Journal of Preventive Medicine (Int J Prev Med)2008-78021142020051922632263ENDepartment of Nutrition, Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, AhvazDepartment of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, AhvazDepartment of Biostatistics and Epidemiology, Faculty of Public Health, Ahvaz Jundishapur University of Medical Sciences, AhvazDepartment of Laboratory Sciences, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, AhvazDepartment of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz20200519<p><span class="fontstyle0"><strong>Background</strong>: </span><span class="fontstyle2">Iron deficiency is prevalent in overweight and obese individuals and may be induced by adiposity‑related inflammation that affect iron metabolism. </span><span class="fontstyle0"><strong>Objective</strong>: </span><span class="fontstyle2">The objective of this study was to investigate the relationship between hematological parameters and obesity‑induced inflammation among young females. </span></p><p><span class="fontstyle0"><strong>Methods</strong>: </span><span class="fontstyle2">A total of 170 young women (aged between 18‑35 years) participated in this cross‑sectional study. Obesity was assessed by BMI (body mass index), WHR (waist to hip ratio), and body fat percentage. Inflammatory and hematological parameters including hs‑CRP (high‑sensitivity C‑reactive protein), serum<br />Fe, hemoglobin, ferritin, transferrin, TIBC (total iron binding capacity) were measured. Dietary intakes of some nutrients (total iron, proteins, calcium, and vitamin C) were assessed according to BMI, WHR and fat mass categories. </span></p><p><span class="fontstyle0"><strong>Results</strong>: </span><span class="fontstyle2">Serum iron were negatively correlated with BMI (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.045, r = -0.154) and hs‑CRP (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.032, r = -0.165). Hemoglobin were also negatively correlated with BMI (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.043, r = -0.155). A significant correlation was also shown between WHR with transferrin (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.034, r = 0.163) and TIBC levels (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.035, r = 0.162), hs‑CRP was positively correlated with BMI (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.014, r = 0.183), WHR (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.009, r = 0.202) and body fat percentage (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.037, r = 0.353). Dietary intakes did not differ significantly among BMI, WHR and fat mass categories (</span><span class="fontstyle3">P </span><span class="fontstyle2">&gt; 0.05). </span></p><p><span class="fontstyle0"><strong>Conclusions</strong>: </span><span class="fontstyle2">Obesity‑induced inflammation, regardless of dietary intake of iron, can lead to iron deficiency. Therefore, weight control, especially in obese subjects is<br />necessary to prevent iron deficiency and anemia.<br /></span></p><p><span class="fontstyle0" style="color: #00652e;"><strong>Keywords</strong>: </span><span class="fontstyle3">Hematological parameters, inflammation, iron deficiency, obesity, young female</span></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2263http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2263/717718100