International Journal of Preventive Medicine (Int J Prev Med)2008-78021182020092723352335ENSocial Determinants of Health Research Center, School of Allied Medical Sciences, Shahrekord University of Medical Sciences, ShahrekordStudent Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran,Cancer Research Development Center, Shahrekord University of Medical Sciences, ShahrekordDepartment of Epidemiology and Biostatistics, School of Health, Shahrekord University of Medical Sciences (SKUMS), ShahrekordDepartment of Adult and Elderly Nursing, Faculty of Nursing and Midwifery, Shahrekord University of Medical Sciences, Shahrekord20200927<p><strong>Background</strong>: Thalassemia is considered as a group of genetic blood disorders, characterized by<br />anemia. The present research aimed at evaluating the effects of aquatic exercise on quality of<br />life and blood indices in patients with beta‑thalassemia major.</p><p><strong>Methods</strong>: A clinical trial study involving 40 patients with thalassemia major, divided into two groups: experimental and control.<br />The tools used to collect the data included demographic information questionnaire, blood indicators<br />questionnaire, and SF‑36 quality of life questionnaire. The experimental group performed exercise<br />in water three times per week for 8 weeks in the pool after obtaining the consent. In this research,<br />the quality of life questionnaire was filled out 24 h before the intervention, 24 h after the last session<br />of the exercise program, and 2 months after the end of the exercise program.</p><p><strong>Results</strong>: The current research revealed that exercise in water affected the quality of life, hemoglobin, hematocrit, iron<br />and ferritin of serum such that the mean score of quality of life and blood indicators in the study<br />showed a significant difference in the experimental group.</p><p><strong>Conclusions</strong>: The use of a regular exercise program combined with drug therapy and blood transfusion can be useful in the treatment<br />of beta‑thalassemia patients.</p><p> </p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2335http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2335/717718177