International Journal of Preventive Medicine (Int J Prev Med)2008-780211122021031723942394EN20210223Dear Editor, We read the publication on “Association of CYP1A1 M2 (A2455G) Polymorphism with Susceptibility to Breast Cancer in Mazandaran Province, Northern Iran: A Case–control Study” with a great interest.[1] Khalili‑Tanha et al. concluded that “M2 allelic genotypes were significantly associated neither with breast cancer risk nor with clinicopathological characteristics in Mazandaran province. [1]” Indeed, the result from this study is concordant with a recent report from China.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2394http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2394/717718248