International Journal of Preventive Medicine (Int J Prev Med)2008-780211122021031724022402ENDepartment of Nephrology, Khorshid Hospital, Isfahan Kidney Diseases Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan20210316<span style="left: 89.8133px; top: 130.982px; font-size: 23.3333px; font-family: sans-serif; transform: scaleX(1.09028);"><span style="left: 94.5378px; top: 208.183px; font-size: 15px; font-family: serif; transform: scaleX(0.934176);">Vitamin D (Vit. D) is among the most important elements of the human body that play pivotal roles </span><span style="left: 94.5378px; top: 226.183px; font-size: 15px; font-family: serif; transform: scaleX(0.967967);">in health and disease. It belongs to the fat-soluble secosteroid family, which is provided by either </span><span style="left: 94.5378px; top: 244.183px; font-size: 15px; font-family: serif; transform: scaleX(0.962401);">foods or direct exposure to sunlight that converts 7-hydroxycholesterol to the Vit. D precursor. An </span><span style="left: 94.5378px; top: 262.183px; font-size: 15px; font-family: serif; transform: scaleX(1.01561);">alternative step is bio‑activation, which delivers an active form of Vit. D </span><span style="left: 540.038px; top: 262.183px; font-size: 15px; font-family: serif; transform: scaleX(1.01119);">(Vit. D3), which participates </span><span style="left: 94.5378px; top: 280.183px; font-size: 15px; font-family: serif; transform: scaleX(1.01225);">in various noticeable functions including calcium regulation, bone remodeling, fertility, glucose </span><span style="left: 94.5378px; top: 298.183px; font-size: 15px; font-family: serif; transform: scaleX(1.04535);">control, and detoxification. The most recent literature is carefully reviewed </span><span style="left: 571.358px; top: 298.183px; font-size: 15px; font-family: serif; transform: scaleX(1.05219);">(2049 articles) and the </span><span style="left: 94.5378px; top: 316.183px; font-size: 15px; font-family: serif; transform: scaleX(1.01684);">relative information was collected and discussed meticulously. Inclusion criteria were the articles that </span><span style="left: 94.5378px; top: 334.183px; font-size: 15px; font-family: serif; transform: scaleX(1.02025);">mentioned the relationship between Vit. D, adipokine, and kidney disease and exclusion criteria were </span><span style="left: 94.5378px; top: 352.183px; font-size: 15px; font-family: serif; transform: scaleX(0.940023);">nonrelevant articles. Vit. D plays several roles in the normal function of the kidney and metabolism. </span><span style="left: 94.5378px; top: 370.183px; font-size: 15px; font-family: serif; transform: scaleX(1.05072);">It has been revealed that Vit. D </span><span style="left: 295.598px; top: 370.183px; font-size: 15px; font-family: serif; transform: scaleX(1.04304);">has a crucial impact on kidney disease and that its deficiency leads </span><span style="left: 94.5378px; top: 388.183px; font-size: 15px; font-family: serif; transform: scaleX(0.96656);">to kidney dysfunction and further renal disorder. Apart from the direct relationship of Vit. D with </span><span style="left: 94.5378px; top: 406.183px; font-size: 15px; font-family: serif; transform: scaleX(0.975896);">kidney disease, the association of adipocytes and adipokines with Vit. D and kidney function has </span><span style="left: 94.5378px; top: 424.183px; font-size: 15px; font-family: serif; transform: scaleX(0.945352);">also been studied. The noticeable role of Vit. D in kidney disease is investigated in various studies. </span><span style="left: 94.5378px; top: 442.183px; font-size: 15px; font-family: serif; transform: scaleX(1.02851);">It has been found that Vit. D has a pivotal role in kidney function and metabolism. Further study can </span><span style="left: 94.5378px; top: 460.183px; font-size: 15px; font-family: serif; transform: scaleX(0.977172);">reveal the better</span><span style="left: 195.908px; top: 460.183px; font-size: 15px; font-family: serif; transform: scaleX(0.969952);">-detailed information about the exact relation of Vit. D and kidney disorders. The </span><span style="left: 94.5378px; top: 478.183px; font-size: 15px; font-family: serif; transform: scaleX(0.936011);">aim of the review was to provide a better insight into the exact role of Vit. D and adipokine in the </span><span style="left: 94.5378px; top: 496.183px; font-size: 15px; font-family: serif; transform: scaleX(0.972994);">kidney disease.</span></span>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2402http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2402/717718234