International Journal of Preventive Medicine (Int J Prev Med)2008-78021232021061324422442ENDepartment of Health Education and Health Promotion, School of Public Health, Iran University of Medical Sciences, TehranDepartment of Cardiology, Tehran Heart Center, School of Medicine, Tehran University of Medical Sciences, TehranDepartment of Community Medicine, Tehran University of Medical Sciences, TehranDepartment of Family Medicine, Tehran University of Medical Sciences, TehranDepartment of Pediatric Cardiology, Rajaie Cardiovascular Medical and Research Center, School of Medicine, Iran University of Medical Sciences, Tehran20210613<p><strong>Background</strong>: Unhealthy lifestyle behaviors are a major concern in the development of metabolic syndrome (MetS). This study aimed to develop, implement, and evaluate a lifestyle education package as a strategy to control the biomedical components of MetS.</p><p><strong>Methods</strong>: A total of 72 women and men (aged 18–68 y) with MetS were selected through randomized sampling. They were classified into 2 groups: an intervention group that received a lifestyle educational package with close followups and a control group that received only usual care. Anthropometric indices, blood pressure, lipid profiles, and fasting blood sugar were assessed at baseline and after 3 months.</p><p><strong>Results</strong>: The lifestylemodification program was associated with a modest weight loss (2 ± 0.4 kg; P &lt; 0.001), a significant reduction in waist circumference (2.3 ± 0.9 cm; P &lt; 0.001) and the hip circumference (1 ± 0.3 cm; P &lt; 0.001), and a sharp decrease in diastolic blood pressure (5.3 ± 1.4 mm Hg; P &lt; 0.001), compared with the baseline values in the intervention group. Additionally, according to the one-way MANOVA analysis, 33.8% of the changes in MetS components were attributable to the educational intervention (P &lt; 0.001, F = 5.27).</p><p><strong>Conclusions</strong>: Improvement in lipid profile and anthropometric measures suggest that a lifestyle package based on multivariable health education is an acceptable method.</p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2442http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2442/717718281