International Journal of Preventive Medicine (Int J Prev Med)2008-78021262021101324742474ENAnesthesiology and Critical Care Research Center, School of Medicine, Isfahan University of Medical Sciences, IsfahanGeneral Physician, School of medicine, Isfahan University of Medical Sciences, IsfahanAnesthesiology and Critical Care Research Center, Department of Anesthesiology and Critical Care, Isfahan University of Medical Sciences, IsfahanAnesthesiology and Critical Care Research Center, Department of Anesthesiology and Critical Care, Isfahan University of Medical Sciences, IsfahanSchool of Medicine, Najaf Abad University of Medical Sciences, Isfahan20211013<p><strong>Context</strong>: Postoperative sore throat (POST) is a common annoying problem following endotracheal (ET) intubation. Aims: Comparing the impact of low and high doses of ketamine gargle on lowering POST incidence and severity. Settings and Design: 96 patients selected for septoplasty surgery under general anesthesia were investigated through a single‑blind randomized controlled trial.</p><p><strong>Methods</strong>: This study was performed on three equal groups. Group K and G gargled 50 and 100 mg ketamine, respectively, solved in normal saline and group C gargled pure normal saline for 30 s at 5 min before tracheal intubation. POST severity measured immediately after the entrance to the postanesthetic care unit (PACU) and then 2 h, 4 h, 8 h, and 24 h after operation. Statistical Analysis Used: Collected data were analyzed by the Chi‑square test, Mann‑Whitney test, Kruskal‑Wallis test, one‑way analysis of variance (ANOVA) and Friedman test using SPSS version 20.</p><p><strong> Results</strong>: POST incidence and severity in group C were significantly higher than both K and G groups at all times. Although significant differences between low and high doses of ketamine were acknowledged at 8 h post‑operation, 100 mg ketamine could attenuate POST severity further than 50 mg at all times.</p><p><strong>Conclusions</strong>: It seems that 100 mg outperformed 50 mg ketamine without rising complications and dissatisfaction for subjects. So, it gives us a powerful reason to suggest gargling 100 mg ketamine for lessening POST incidence and severity</p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2474http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2474/717718314