International Journal of Preventive Medicine (Int J Prev Med)2008-78021262021101324812481ENFaculty of Nursing, Chulalongkorn University Bangkok, Thailand & Nursing Program, STIKes Wira Medika Bali, IndonesiaAssociate Professor, Faculty of Nursing, Chulalongkorn University Bangkok,Postdoctoral Researcher, Faculty of Nursing, Chulalongkorn University BangkokNursing Program, STIKes Wira Medika BaliNursing Program, STIKes Wira Medika Bali20211013Comprehensive care includes the spiritual and the bio-psycho-social person. The aim of this study is to explain how people with diabetes mellitus manage holistic treatment. Search for multidatabase papers: Ovid, CINAHL, and PubMed. PICOT-based keyword description is P: any diabetes population, I: holistic care, C: any comparison, O: blood sugar, T: whenever. The English article, journal quest, full-text article available, and published article were criteria for inclusion in this study. In the quest journal, a strategic manner is performed using three keywords: holistic, diabetes mellitus, and blood sugar. We reviewed ten papers. The result showed that comprehensive care was explained in terms of technology, holistic care program, and holistic care relating to complementary alternative medicine. Discussion in this study is that holistic care services give significant results in the treatment of people with diabetes mellitus.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2481http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2481/717718321