International Journal of Preventive Medicine (Int J Prev Med)2008-78021262021101324832483ENDepartment of Health Services Management, Student Research Committee, School of Management and Medical Information Sciences, Health Management and Economics Research Center, Isfahan University of Medical Sciences, IsfahanAustralasian Nanoscience and Nanotechnology Initiative (ANNI), 8054 Monash University LPO, Clayton, Victoria 3168, Australia & Supreme NanoBiotics Co. Ltd. and Supreme Pharmatech Co. Ltd., 399/90-95 Moo 13 Kingkaew Rd. Soi 25/1, T. Rachateva, A. Bangplee, Samutprakan 10540, ThailandDepartment of Medical Library and Information Sciences, Health Information Technology Research Center, Student Research Committee, School of Management and Medical Information Sciences, Isfahan University of Medical Sciences, IsfahanDepartment of Health Services Management, Health Management and Economics Research Center, Isfahan University of Medical Sciences, Isfahan20211013<p><strong>Background</strong>: The basis of prevention of non‑communicable diseases is the identification of primary risk factors and the prevention and control of these factors. The purpose is to prevent the spread of the disease and to control it as much as possible. If population growth continues at this rate, by 2030, 52 million people will die from these diseases each year. The aim of this study was to evaluate the challenges of preventing non‑communicable diseases.</p><p><strong>Methods</strong>: The present study was a systematic review that conducted in July 2020 and the articles related to prevention of non‑communicable diseases on databases of web of science, PubMed, Scopus, science direct, Ovid, Pro Quest and Google Scholar. Strategy for searching and selecting the articles was PRISMA Guidelines.</p><p><strong>Results</strong>: Challenges of non‑communicable disease prevention, in 4 main codes, including infrastructure, economic, demographic and management and 12 sub‑codes that include, lack of preventive infrastructure, restrictions on access to medicine, restrictions on primary health care, restrictions on access to Technology, disease‑oriented disease, unsustainable financial resources, failure to implement poverty reduction projects, increase in aging population, migration, rapid and unplanned urban planning, hasty planning and lack of internal and external coordination were classified.</p><p><strong>Conclusions</strong>: To reduce non‑communicable diseases, strengthen global capacities, reduce risk factors for NCDs and place social determinants by creating health‑promoting environments, strengthen health systems to implement prevention and control of NCDs, and place determinants Social can play an effective role through people‑centered primary health care</p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2483http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2483/717718323