International Journal of Preventive Medicine (Int J Prev Med)2008-780212112022010325662566ENDepartment of Psychology, Faculty of Education and Psychology, Shahid Beheshti University, TehranDepartment of Psychology, Faculty of Education and Psychology, Shahid Beheshti University, TehranDepartment of Applied Psychology, Faculty of Education and Psychology, Shahid Beheshti University, TehranDepartment of Psychology, Faculty of Education and Psychology, Shahid Beheshti University, TehranDepartment of Psychology, Faculty of Education and Psychology, Shahid Beheshti University, Tehran20220102Background: Over the last 20 years, internet‑delivered cognitive behavior therapy (ICBT) has been tested in a large number of randomized controlled trials, often with positive results. However, it is not widely known about the efficacy of ICBT as compared to face‑to‑face cognitive behavior therapy (CBT). Methods: In the present systematic review and meta‑analysis, ICBT for treatment of anxiety disorders was directly compared to face‑ to‑face CBT within the same trial. This study aimed to reinvestigate the effect of ICBT compared to face‑to‑face CBT for anxiety disorders. A total of 8 studies out of the 236 articles screened met all the inclusion criteria. The included studies targeting five different anxiety disorders, social anxiety disorder, adolescent anxiety, panic disorder, spider phobia, and fear of public speaking, had been carried out in Australia, Spain, and Sweden. The total number of participants was 348 in ICBT and 316 in face‑to‑face conditions. Results: The results of our meta‑analysis are interesting both from theoretical and practical standpoints, which showed a pooled effect size posttreatment with Hedges’ g = 0.01 (95% CI: −0.16 to 0.18), Conclusions: ICBT and face‑to‑face CBT created equivalent overall effects. in treatment of anxiety disorders. Since there have been similar systematic reviews about anxiety disorders so far, and in majority of them, ICBT has not been compared against face‑to‑face treatment. More research is needed to establish the general equivalence of the two treatment formats. Also, understanding what makes ICBT work is a challenge for future research.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2566http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2566/717718406