International Journal of Preventive Medicine (Int J Prev Med)2008-78021342022071726582658ENRazi Drug Research Center, Iran University of Medical Sciences, TehranChronic Respiratory Disease Research Center(CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, TehranHerbal and traditional medicines research center, Kerman university of medical sciences, KermanSchool of PharmacyInternational Campus, Iran University of Medical Sciences, TehranRazi Drug Research Center, Iran University of Medical Sciences, TehranRazi Drug Research Center, Iran University of Medical Sciences, TehranRazi Drug Research Center & Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran20220717<strong>Background</strong>: As a psychostimulant agent, methylphenidate (MPH) abuse can cause serious liver damage. Studies have documented the hepatoprotective impacts of curcumin on liver damage. According to this definition, the purpose of this study is to explain the hapatoprotective effects of curcumin against the hepatotoxicity induced by MPH. <strong>Methods</strong>: Seventy rats were equally divided into seven groups (10 rats per group). Groups 1 and 2 received normal saline (0.7 mL/rat) and MPH (10 mg/kg), respectively for 21 days. Groups 3, 4, 5, and 6 concurrently received MPH (10 mg/ kg) and curcumin (10, 20, 40, and 60 mg/kg, respectively) for 21 days. Group 7 was treated with curcumin (60 mg/kg) alone for 21 days. The hepatic function test key enzymes such as AST, ALP, and histology of liver tissue (ALT), and alkaline phosphatase (ALP) levels was studied in the blood samples, and also, the histopathological changes and cell density changes were evaluated in the liver tissue. <strong>Results</strong>: The latest studies have shown that the administration of MPH induces rises in the AST, ALT, and ALP levels and induces degeneration changes in histopathology, whereas curcumin administration at doses of 40 and 60 mg/kg reduced the elevation of MPH‑induced hepatic enzyme and inhibited histopathological degeneration in the MPH‑treated classes. Curcumin alone (60 mg/kg) did not alter the biochemical and histological parameters. <strong>Conclusions</strong>: Curcumin can function as a hepatoprotective agent against MPH‑induced hepatotoxicity.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2658http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2658/717718495