International Journal of Preventive Medicine (Int J Prev Med)2008-78021412023031927562756ENDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, IsfahanDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, IsfahanDepartment of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, IsfahanDepartment of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Isfahan University of Medical Sciences, IsfahanIsfahan Center of Health Research, National Institute of Health Research, Isfahan20230304<p><strong>Background</strong>: The present study aimed to investigate the effect of garlic supplementation on oxidative stress markers in patients with polycystic ovary syndrome (PCOS).</p><p><strong>Methods</strong>: Eighty patients with PCOS were randomized and instructed to consume either garlic supplementation (800 mg/day) or a placebo (starch) for 8 weeks. They were also asked to avoid intake of any other supplement during the study. Oxidative stress‑related markers including total antioxidant capacity, catalase, glutathione, malondialdehyde concentrations, and anthropometric measures were assessed at baseline and end of the trial.</p><p><strong>Results</strong>: Garlic supplementation resulted in significant improvement in catalase concentration (1.82 ± 9.28 vs. –1.55 ± 8.66; P value: 0.03), glutathione levels (29.15 ± 57.53 vs. 2.42 ± 77.51; P value: 0.048) as well as weight (–0.64 ± 1.94 vs. 0.11 ± 0.82; P value: 0.04), body mass index (BMI; –0.25 ± 0.75 vs. 0.05 ± 0.61; P value: 0.04), and waist circumference (–0.21 ± 0.77 vs. 0.02 ± 0.65; P value: 0.01). However, we failed to detect any significant change in hip circumference, waist to hip circumference ratio, total antioxidant capacity, and malondialdehyde levels between the two groups.</p><p><strong>Conclusions</strong>: The present study indicates that garlic supplementation could be beneficial in improving oxidative stress and weight loss among PCOS women.</p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2756http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2756/717718601