International Journal of Preventive Medicine (Int J Prev Med)2008-78021412023031927672767ENStudent Research Committee, Department of Community Health Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences & Department of Research, School of Nursing, Bank Melli Iran, TehranDepartment of Community Health Nursing , School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, TehranDepartment of Community Health Nursing , School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, TehranBasic Sciences, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, TehranDepartment of Nursing, Bojnurd Faculty of Nursing, North Khorasan University of Medical Sciences, BojnurdDepartment of Mathematics and Computer Science, Faculty of Statistics, Amirkabir University of Technology, Tehran20230319<strong>Background</strong>: Education of the patients with Coronavirus Disease 2019 (COVID‑19) and their families is necessary to improve the quality of life. This study investigated the effect of person and family‑centered training via telenursing on the quality of life in patients with COVID‑19. <strong>Methods</strong>: This interventional study was performed on 88 patients with COVID‑19 18‑‑65 years and 44 family members referred to the Bank Melli Hospital, Tehran, Iran. The samples were randomly assigned into two groups person‑centered and family centered. A cyberspace group including patients and their families was created. Four educational sessions planned (15‑‑30‑min‑every day) and three sessions planned for completing the questionnaires via phone. The data were collected using demographic characteristics form and the 12‑item Short‑Form Health Survey version 2 before and 6 weeks after the intervention and were analyzed in SPSS 22 using Chi‑square test, paired t‑test, and independent t‑test. <strong>Results</strong>: The mean scores of quality‑of‑life increased significantly in the person‑centered group from 26.81 ± 5.15 to 34.4 ± 4.39 before and six weeks after intervention, respectively (p &lt; 0.001). The means scores of quality‑of‑life increased significantly in the family‑centered group from 28.11 ± 4.79 to 35.86 ± 3.85 before and 6 weeks after the intervention, respectively. (p &lt; 0.001). <strong>Conclusions</strong>: The person and family centered methods increase the mean scores of quality‑of‑life of patients with COVID‑19. The family centered method can be more effective to improve the quality of life of these patientshttp://ijpm.mui.ac.ir/index.php/ijpm/article/view/2767http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2767/717718606