International Journal of Preventive Medicine (Int J Prev Med)2008-780214220230403A Deeper View of Early Life Microbiota and Hygiene Hypothesis Relationship: Reducing the Risk of Allergic Diseases is Dependent on the Permanent Presence of Good Microbiota throughout Life27772777ENDepartment of Cell and Molecular Biology and Microbiology, Faculty of Biological Sciences and Technology, University of Isfahan, Isfahan20230319After 30 years, the Hygiene Hypothesis is still being debated in the scientific community. The essence of Hygiene Hypothesis is that exposure of the immune system to microbes in early life prevents allergic disease later in life.[1] In other words, people who live in rural areas have a low risk for allergic disease than in urban areas. The concept of this hypothesis backs to the balance of the Th1/2 responsehttp://ijpm.mui.ac.ir/index.php/ijpm/article/view/2777http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2777/717718618