International Journal of Preventive Medicine (Int J Prev Med)2008-78021462023073028402840ENSchool of Medicine, Najafabad Branch, Islamic Azad University, IsfahanSchool of Medicine, Isfahan University of Medical Sciences, IsfahanDepartment of Neurology, School of Medicine, Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, IsfahanSchool of Medicine, Najafabad Branch, Islamic Azad University, IsfahanDepartment of Biostatistics and Epidemiology, Faculty of Health, North Khorasan University of Medical Sciences, BojnurdSchool of Medicine, Isfahan University of Medical Sciences, IsfahanSchool of Medicine, Isfahan University of Medical Sciences, Isfahan20230729Background: Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating, immune‑mediated disease of the central nervous system. It is still unestablished whether heredity correlates with the disease’s progression and severity. Methods: This study includes the patients with MS seen in the MS clinic of Kashani Hospital, affiliated with Isfahan University of Medical Sciences, from January 2019 to January 2020. We gathered data regarding the demographic and clinical characteristics, such as type of disease and family history of MS. Patients were grouped based on having relatives with MS. We compared demographic and clinical characteristics between those with a family history of MS (familial MS: FMS) and those without a family history of MS (sporadic MS: SMS). Results: We included 2,929 MS patients, 523 (17.2%) with FMS and 2,406 (82.8%) with SMS. Patients with FMS were found to have active lesions in the thoracic spine more frequently than those with SMS (P = 0.022). We also found differences in the distribution of gender (P = 0.036) and the frequency of having active brain lesions (P = .024) among patients with FMS and SMS. No difference was found between the demographic/clinical characteristics and the number of affected relatives in the family. Conclusions: Significant differences were found among different groups of patients in terms of demographical and clinical characteristics.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2840http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2840/717718707