International Journal of Preventive Medicine (Int J Prev Med)2008-78021472023091928532853ENDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Center of Health Research, National Institute of Health Research, Isfahan, Iran20230919Background: The purpose of the present study was to investigate the effect of garlic supplementation on androgen levels and glycemic‑related markers in patients with PCOS. Methods: In these 8 weeks of randomized double‑blinded control trial, 80 women were randomly assigned into two groups in which patients were asked to intake either 800 mg/day garlic or an identical placebo. A blood sample was obtained pre‑ and post‑trial to assess androgens and glycemic‑related parapets. A 3‑days‑ food record and a short form of international physical activity questionnaires (IPAQ) were also evaluated at the beginning and end of the trial. Results: All participants completed the trial. Garlic supplementation resulted in significant reduction in fasting plasma glucose (‑3.22 ± 7.41 vs. 0.72 ± 5.37; P = 0.008) and homeostatic model assessment for insulin resistance (HOMA‑IR) (‑0.29 ± 1.45 vs. 0.28 ± 1.20; P = 0.02). In addition, a trend to a significant improvement was detected in free androgen index (FAI) (P = 0.09), insulin levels (P = 0.07), and quantitative insulin sensitivity check index (QUICKI) (P = 0.06). However, no significant difference was found in testosterone and sex hormone‑binding globulin (SHBG) (P > 0.05). Conclusions: Present study indicates that garlic supplementation could be beneficial for FPG and insulin resistance improvement. However, garlic supplementation does not show remarkable efficacy on androgens. Further studies are warranted to confirm the results.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2853http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2853/717718676