International Journal of Preventive Medicine (Int J Prev Med)2008-780216320250423114EN1 Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran, 2 Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan3 Center for Mathematics and Applications (NOVA Math), NOVA School of Science and Technology (NOVA SST), Caparica4 Department of Statistics, Faculty of Statistics, Mathematics and Computer, Allameh Tabataba’i University, Tehran2 Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran 5 CREB, Universitat Politècnica de Catalunya, BarcelonaTech (UPC), Barcelona, Spain6 Biomedical Engineering Department, Engineering Faculty, University of Isfahan, Iran 7 Biomedical Engineering Research Centre (CREB), Automatic Control Department (ESAII), Universitat Politècnica de Catalunya-Barcelona Tech (UPC) Building H, Floor 4, Av. Diagonal 647, 08028 Barcelona, Spain 8 Department of Artificial Intelligence, Smart University of Medical Sciences, Tehran, Iran20250415<p>Background: To provide a detailed understanding and apply a comprehensive strategy, this study examines the association between COVID‑19 vaccination and cardiovascular events. We conducted a Bayesian multivariate meta‑analysis using summary data across multiple outcomes including myocardial infarction, stroke, arrhythmia, and CAD, considering potential dependencies in the data. Markov chain Monte Carlo (MCMC) methods were detected for easy implementation of the Bayesian approach. Also, the sensitivity analysis of the model was done by using different priors. Methods: Fifteen studies were included in the systematic review, with eleven studies comparing the results between the vaccine group and the unvaccinated group. Additionally, six studies were used for further analysis to compare mRNA COVID‑19 Vaccines (Pfizer‑BioNTech and Moderna). Results: Bayesian meta‑analysis revealed a link between vaccines and CAD risk (OR, 1.70; 95% CrI: 1.11–2.57), particularly after BNT162b2 (OR, 1.64; 95% CrI: 1.06–2.55) and second dose (OR, 3.44; 95% CrI: 1.99–5.98). No increased risk of heart attack, arrhythmia, or stroke was observed post‑COVID‑19 vaccination. As the only noteworthy point, a protective effect on stroke (OR, 0.19; 95% CrI: 0.10–0.39) and myocardial infarction (OR, 0.003; 95% CrI: 0.001–0.006) was observed after the third dose of the vaccine. Conclusions: Secondary analysis showed no notable disparity in cardiovascular outcomes between BNT162b2 and mRNA vaccines. The association of COVID‑19 vaccination with the risk of coronary artery disease should be considered in future vaccine technologies for the next pandemic.</p><p> </p><p><span class="ej-journal-name" style="box-sizing: inherit; font-style: italic; font-weight: 500; color: #3b3030; font-family: 'Fira Sans', sans-serif; font-size: 14px; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">International Journal of Preventive Medicine<span> </span></span><span id="ej-journal-date-volume-issue-pg" style="box-sizing: inherit; color: #3b3030; font-family: 'Fira Sans', sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><a style="box-sizing: border-box; color: #005b92; text-decoration: none; background-color: transparent; cursor: pointer; outline: 0px;" href="https://journals.lww.com/ijom/pages/currenttoc.aspx">16():14, March 2025.</a></span><span style="box-sizing: inherit; color: #3b3030; font-family: 'Fira Sans', sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><span> </span>|<span> </span></span><span class="ej-journal-doi" style="box-sizing: inherit; font-style: italic; font-weight: 500; color: #3b3030; font-family: 'Fira Sans', sans-serif; font-size: 14px; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">DOI:<span> </span></span><span style="color: #3b3030; font-family: 'Fira Sans', sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;">10.4103/ijpvm.ijpvm_260_24</span></p><p>Corresponding Author: Dr. Marjan Mansourian</p><p>E‑mail:jmansourian@hlth.mui.ac.ir</p><p>You can also search for this author in: <a title="PubMed" href="https://pubmed.ncbi.nlm.nih.gov/?term=%28Marjan+Mansourian%5BAuthor%5D%29+AND+%28Isfahan+University+of+Medical+Sciences%5BAffiliation%5D%29&amp;sort=">PubMed</a> <a title="google scholar" href="https://scholar.google.com/citations?user=PQ1j0agAAAAJ&amp;hl=en&amp;oi=ao">Google Scolar</a></p>http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2983http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2983/717718824