International Journal of Preventive Medicine (Int J Prev Med)2008-78023420120327599599ENWiwanitkit House, Bangkhae, Bangkok, Thailand 1016020120327I read the recent publication on children contacting with smear positive tuberculosis patients with great interest.[1] Aminzadeh <em>et al</em>. concluded that the &lsquo;Strategy of six months of supervised isonicotinylhydrazine (INH) chemoprophylaxis is successful, particularly in children who are at high risk to progress to the disease, following exposure.[1] I agree with the usefulness and effectiveness of such a practice. However, I am concerned about the possible side effects of chemoprophylaxis on the children. A further cost-benefit weighting study is warranted.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/599http://ijpm.mui.ac.ir/index.php/ijpm/article/download/599/437