International Journal of Preventive Medicine (Int J Prev Med)2008-78024720120412845848ENDepartments of Surgery, Maharishi Markandeshwer Institute of Medical Sciences and Research, Haryana, IndiaDepartments of Surgery, Maharishi Markandeshwer Institute of Medical Sciences and Research, Haryana, IndiaDepartments of Surgery, Maharishi Markandeshwer Institute of Medical Sciences and Research, Haryana, IndiaDepartment of Radio‑oncology, Government Medical College, Punjab, IndiaDepartments of Surgery, Maharishi Markandeshwer Institute of Medical Sciences and Research, Haryana, IndiaDepartment of Surgery- Maharishi Markandeshwer Institute of Medical Sciences and Research, Mullana , (Distt - Ambala), Haryana, IndiaDepartments of Surgery, Maharishi Markandeshwer Institute of Medical Sciences and Research, Haryana, IndiaDepartment of Radiology, Maharishi Markandeshwer Institute of Medical Sciences and Research, Haryana, India20120412<p>In females, the most common cancer is breast carcinoma in which squamous cell carcinoma (SCC) is a rare type of malignancy. Histologically, infiltrating ductal carcinoma is the most common type and lobular, mucinous, and medullary types have lower incidence. Pure SCC of the breast can originate from the skin, nipple, or epithelium of a deep‑seated dermoid cyst or squamous metaplasia on chronic inflammation background. We are reporting a rare case of primary SCC of the breast in a 45‑year‑old female. In follow‑up of 8 months, patient is doing well. We discussed our approach for treatment with review of the literature. We have treated this patient successfully with surgical and adjuvant chemotherapy.</p> <strong>Keywords: </strong>Breast, chemotherapy, surgery, squamous carcinomahttp://ijpm.mui.ac.ir/index.php/ijpm/article/view/640http://ijpm.mui.ac.ir/index.php/ijpm/article/download/640/1088