International Journal of Preventive Medicine (Int J Prev Med)2008-78023520120414663663ENDepartment of Surgery, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Surgery, Isfahan University of Medical Sciences, Isfahan, IranMedical Student Research Center, Isfahan University of Medical Sciences, Isfahan, IranMedical Student Research Center, Isfahan University of Medical Sciences, Isfahan, IranMedical Education Research Center, Isfahan University of Medical Sciences, Isfahan, Iran20120414Peri-ampullary and pancreatic head cancer can cause significant morbidity and mortality among gastrointestinal malignancies in human beings because of its important anatomy and physiology.[1] This tumor is responsible for about 150,000 deaths annually all over the world, and is categorized as the 5th leading causes of death among the malignancies. [2] Pancreaticoduodenectomy (PD) is the complex palliative procedure for patients affecting peri-ampullary and pancreatic head tumors, benign neoplasm and for other conditions such as chronic pancreatitis showing obstructive jaundice as a common symptom, which was first time invented by Whipple <em>et al</em>.[3-7] Despite best palliative and occasionally curativeness of this procedure, there are some contraindications for the surgery including: Metastasis to distant organs, tumor infiltration to mesenteric and portal vessels and affecting small bowel mesentery by tumoral mass.[8]http://ijpm.mui.ac.ir/index.php/ijpm/article/view/663http://ijpm.mui.ac.ir/index.php/ijpm/article/download/663/521