Aspects of epidemiology, pathology, virology, immunology, transmission, prevention, prognosis, diagnosis, and treatment of COVID-19 Pandemic: A narrative review

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Aspects of epidemiology, pathology, virology, immunology, transmission, prevention, prognosis, diagnosis, and treatment of COVID-19 Pandemic: A narrative review24482448ENSocial Determinants of Health Research Center, & Department of Epidemiology and Biostatistics, Semnan University of Medical Sciences, Semnan20210903Undoubtedly, COVID‑19 pandemic is one of the largest pandemics and one of the biggest international challenges for health‑care system of various countries in the world. This is a narrative review study based on the studies published related with different aspects of COVID‑19. The highest numbers of active cases are in the USA, Brazil, India, Russia, South Africa, as well as Colombia and the disease surveillance system must operate more quickly, timely, effectively, and sensitively in these countries. What is clear is that the SARS‑CoV‑2 basic reproduction number is significantly higher than one and its transmission power is extremely high. In general, it can be stated that mortality and fatality risk due to COVID‑19 in men, age increase, severity of disease, systemic disease, as well as inadequate access to the sufficient health‑care services will increase. There is currently no specific treatment and effective vaccine for COVID‑19. The novel coronavirus pandemic is more consistent with the epidemiological triangle model, which emphasizes that the disease is the result of the interaction of three factors of host, agent, and environment. Therefore, prevention and treatment activities should focus on cutting the virus transmission chain. The main way to deal with viral epidemics is prevention. The emerging of this ruthless virus has once again reminded us that communicable diseases should never be underestimated and forgotten. Considering the rapid transmission of COVID‑19, the health‑care authorities and workers should consider timely detection and safeguards to prevent the transmission to healthy individuals.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2448http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2448/717718287

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929The Cost‑Effectiveness and Cost‑Utility of Statin Drug for the Treatment of Patients with Cardiovascular Disease, A Systematic Review24492449ENAssistant Professor, Faculty of Economics, Allameh Tabataba'i University, TehranDepartment of Medical Library and Information Sciences, Health Information Technology Research Center, Student Research Committee, School of Management and Medical Information Sciences, Isfahan University of Medical Sciences, IsfahanHealth Management and Economics Research Center, Iran University of Medical Sciences, TehranDepartment of Health Services Management, School of Health, Ahvaz University of Medical Sciences, AhvazDepartment of Health Care Management, Health Management and Economics Research Center, Student Research Committee, School of Management and Medical Information Sciences, Isfahan University of Medical Sciences, IsfahanHealth Human Resources Research Centre, School of Management and Medical Information Sciences, Shiraz University of Medical Sciences20210903Cardiovascular diseases impose a burden of disease and economic burden on society. With regard to different drugs are used to treat cardiovascular disease; these interventions should be economically evaluated and them that the most cost‑effective were selected. The aim of this study was to investigate the studies carried on the cost‑effectiveness and cost‑utility of statin drugs for the treatment of patients with cardiovascular disease between 2004 and 2020. Quality assessment of the articles was examined by Drummond’s checklist. Given that the inclusion criteria, 26 articles included in the review. The results of this review showed that many articles related to the economic evaluation of statin drugs adhered international standards for performing economic evaluation studies. All the studies mentioned the source of effectiveness (the second criteria) and alternative options for the comparison (the third criteria). Atorvastatin and rosuvastatin drugs were the main options for the comparison in the studies. Although the results of the studies were different in some aspects, such as the type of modeling, costs items and the study perspective, they reached the same results which the use of statin drugs versus no‑drug can decrease cost, cardiovascular events and deaths and increase QALY. The results were nearly different due to study design, time horizon, efficacy, and drug prices.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2449http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2449/717718288

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Effect of Vitamin D supplements on relapse rate and Expanded Disability Status Scale (EDSS) in multiple sclerosis (MS): A systematic review and meta-analysis24502450ENResearch Center for Immunodeficiencies, Tehran University of Medical Sciences; Universal Scientific Education and Research Network, TehranMultiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical Sciences, TehranDepartment of Radiology, Zanjan University of Medical Sciences, ZanjanF Hoffman-La Roche, BaselMultiple Sclerosis Research Center, Neuroscience institute; Universal Council of Epidemiology, Universal Scientific Education and Research Network, Tehran University of Medical Sciences, Tehran20210903<strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Background:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> Multiple sclerosis (MS) is an inflammatory disease while there are controversies regarding the role of vitamin D supplements in controlling relapse and disability improvement during treatment. <strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Objective:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> The goal of this systematic review and meta-analysis was to evaluate the effect of vitamin D supplements on MS-related relapse and the Expanded Disability Status Scale (EDSS). <strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Methods:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> We searched databases to include randomized clinical trials (RCTs) which were published up to October 2018. We included RCTs, being single-blinded or double-blinded or open-label trials in which one of the main outcomes was EDSS and/or relapse after vitamin D supplementation. All statistical analyses were performed using RevMan 5.3. Odds ratios (OR) and 95% confidence intervals (CI) were calculated for relapse between treatment arms. The mean difference was calculated for EDSS comparisons. <strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Results:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> Nine articles were included for analysis. Of these nine studies, five compared vitamin D supplement groups with placebo (group 1 studies), and four compared high- and low-dose vitamin D groups. A total of 561 patients were analyzed. Being treated with vitamin D instead of placebo showed no effect on relapse rate (OR = 0.66, 95% CI = 0.28–1.54) as well as EDSS (mean difference = 0.06, 95%CI [-0.31, 0.42]). The results of studies comparing high- vs. low-dose vitamin D interventions showed no significant effect on relapse rate (OR = 1.08, 95%CI [0.29–4.08] as well as final EDSS (mean difference = 0.17, 95% CI = -0.73, 1.07). <strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Conclusions:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> Our findings show that vitamin D supplements (high or low dose) have no significant effect on relapse rate and disability during treatment in MS patients.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2450http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2450/717718289

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Systematic review and meta-analysis on quality of life in diabetic patients in Iran24532453ENTraditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran Sari, University of Medical Sciences, Sari,Research Center for Environmental Determinants of Health (RCEDH), School of Public Health, Kermanshah Uninversity of Medical Sciences, KermanshahMedical Student at school of medicine, Mazandaran University of Medical Sciences, Sari,Social Determinants of Health Research Center, School of Allied Medical Sciences, Shahrekord University of Medical Sciences, ShahrekordResearch Center for Environmental Determinants of Health (RCEDH), School of Public Health, Kermanshah Uninversity of Medical Sciences, Kermanshah20210903<strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Background:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> Diabetes is the fifth leading cause of death in the world, which reduces the patients' quality of life (QOL) and is considered as an important subject especially in medicine and medical community. The present study aimed at investigating the QOL of diabetic patients in Iran through meta-analysis. <strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Methods:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> The search was conducted using relevant keywords in national and international databases including Iranmedex, SID, Magiran, IranDoc, Medlib, Science Direct, PubMed, Scopus, Cochrane, Embase, Web of Science. Questionnaires WHOQOL, SF-36, SF-20, DQOL, QOL, PedsQL, ADDQOL, D-39, DQOL-BCI, SWED-QUAL, IRDQOL, PHG-2, EQ-5D, and IDQOL-BCI were used to assess the QOL. Heterogeneity of studies was assessed using I<sup style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">2<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> index. Data were analyzed using STATA version 11. <strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Results:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> In 96 studies of 17,994 people, the mean score of QOL in diabetic patients was based on the questionnaires WHOQOL [66.55 (95% CI: 45.83, 87.26)], D-39 [129.43 (95%CI: 88.77, 170.10)], SF-36 [65.64 (95% CI: 59.82, 71.46)], SF-20 [46.50 (95% CI: 37.19, 55.81], DQOL [61.19 (95% CI: 35.73, 86.66)], QOL [117.91 (95% CI: -62.97, 298.79)], PedsQL [34.36 (95% CI: -31.49, 100.22)], ADDQOL [41.76 (95% CI: 12.01-71.50)], SWED-QUAL [59.19 (95% CI: 21.15, 97.23)], IRDQOL [105.92 (95% CI: 102.73, 109.10)], PHG-2 [61.00 (95%CI: 59.63, 62.37)], EQ-5D [0.62 (95% CI: 0.61, 0.64)], DQOL-BCI [3.40 (95% CI: 3.31, 3.49)], and IDQOL-BCI [22.63 (95% CI: -2.38, 47.64)]. <strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Conclusions:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> The QOL of diabetic patients was evaluated according to different types of questionnaires and the QOL of diabetic patients was found to be lower than normal population.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2453http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2453/717718292

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Significance of serum protein electrophoresis in the detection of multiple myeloma: A diagnostic interpretation of patients with varied immunoglobulins24512451ENDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical SciencesDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical SciencesDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical SciencesDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical SciencesDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical SciencesDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical SciencesDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical SciencesDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical SciencesDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical Sciences20210903<strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Background:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> To determine the relationship between serum protein electrophoresis (SPE) and serum immunoglobulin profiles of patients with multiple myeloma (MM). <strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Methods:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> This is a retrospective study conducted at the Eric Williams Medical Sciences Complex, focusing on patients over 18 years who received diagnostic blood tests for MM. Results for SPE and serum immunoglobulin profiles were obtained using lab logbooks. Descriptive and inferential statistics techniques were used to analyze the data. <strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Results:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> The median age of MM patients in Trinidad and Tobago is of 69 years. The ratio of male and female patients with the MM is 50:50. Out of 131 patients, 24 (18.32%) had M bands present, 60 (45.80%) had an increase in gamma globulin, and 16 (12.21%) had a decrease in albumin. In cases of M band presence and raised gamma, there was noticeable increase in IgG concentration and a slight increase in IgM concentration. There was also an increase in IgA concentration in patients with the M-band but a decrease in concentration in those with raised gamma. Patients with an elevated gamma had a significant increase in IgG diameter and IgG concentration. <strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Conclusions:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> This study showed a relationship between the presence of M bands and serum immunoglobulins. It has proven the significance of SPE and immunoglobulins, like IgG and IGM, in the detection of MM in the early and advanced stages. Therefore, it is recommended that SPE be used, along with other laboratory tests, in the diagnosis of MM.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2451http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2451/717718290

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Analgesic and anti-inflammatory effects of hydroalcoholic and hexane extracts of Smyrniopsis aucheri in animal models24522452ENDepartment of Pharmacology and Toxicology and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, IsfahanDepartment of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, IsfahanDepartment of Pharmacology and Toxicology and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan20210903<strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Background:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> The fruits of Apiaceae family have been widely used in traditional medicine for the treatment of pain and inflammation. In this study, we evaluated the analgesic and anti-inflammatory effects of wild celery (<em style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Smyrniopsis aucheri<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;">) seeds, as a member of the Apiaceae family. <strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Methods:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> Hydroalcoholic and hexane extracts of seeds were prepared and for the evaluation of analgesic activity, acetic acid, formalin, and hotplate tests in male mice (20–30 g) and for anti-inflammatory assessment carrageenan-induced paw edema in rats and croton oil-induced ear edema in mice were used. <strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Results:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> Hydroalcoholic and hexane extracts (100–400 mg/kg) significantly reduced abdominal spasms in the acetic acid test. In the formalin test, the hydroalcoholic extract at doses of 200 and 400 mg/kg reduced the pain of the chronic phase while hexane extract was effective in both acute and chronic phases. In the hot plate test, both extracts were ineffective. In the carrageenan and croton tests, both extracts at a dose of 400 mg/kg significantly reduced edema. <strong style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Conclusions:<span style="color: #000000; font-family: Arial, Verdana, Geneva, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"> The results revealed the analgesic and anti-inflammatory effects of plant seed extracts. Due to the lack of response of the extracts in the hot plate test, it seems that the plant mainly has a peripheral analgesic effect.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2452http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2452/717718291

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Preventive Effect of Eucalyptol on the Formation of Aorta Lesions in the Diabetic‑Atherosclerotic Rat24562456ENDepartment of Clinical Biochemistry, Faculty of Medicine, Ardabil University of Medical Sciences, ArdabiDepartment of Endocrinology and Metabolism, Faculty of Medicine, Tehran University of Medical Sciences, Tehran20210908Background: Glycation, inflammation, and oxidative stress are the cardinal motivators of diabetes vascular complications. Here, we studied the effect of eucalyptol(EUC) on the formation of atheromatous lesions, glycation, oxidative stress, and inflammatory markers as well as insulin resistance, lipid profile, and activity of glyoxalase‑1(GLO‑I) in the atherosclerotic rat model. Methods: Diabetic‑atherosclerosis induced in rats with a combination of streptozotocin and atherogenic diet. Two groups of rats, normal and diabetic‑atherosclerotic, were treated intragastrically with EUC(200 mg/kg) once daily for 3 months. Fasting blood sugar(FBS), insulin, insulin resistance index, lipid profile, the activity of GLO‑I, low‑density lipoprotein(LDL) glycation and oxidation markers, inflammatory markers, creatinine in the serum, and proteinuria in the urine of all rats were determined. Results: EUC inhibited the formation of any atheromatous lesions in atherosclerotic rats. Further, EUC displayed the lowering effect on glycemia, insulin resistance, LDL glycation, and oxidation products, and tumor necrosis factor(TNF)‑α as well as it exhibited the improving effect on lipid profile, the activity of GLO‑I, and renal function in the diabetic rat(P<0.001). Conclusions: EUC prevented the formation of the atheromatous lesions and improved renal function in the atherosclerotic rat model due to a reduction of glycation, oxidative stress, and inflammatory mediators.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2456http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2456/717718295

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Selenium, Zinc, and Copper Status in Euthyroid Nodular Goiter: A Cross‑Sectional Study24572457ENDepartment of Endocrinology and Metabolic Disease, Faculty of Medicine, Yozgat Bozok University, YozgatDepartment of Public Health, Faculty of Medicine, Yozgat Bozok University, Yozgat20210908Background: It is known that some elements are needed for normal thyroid gland functions. Iodine and selenium are the most well‑known trace elements necessary for thyroid metabolism. Selenium is involved in the formation of thyroid hormones and the structure of the deiodinases associated with the development of the thyroid gland. While the role of zinc in thyroid metabolism is at the T3 receptor level, the role of copper is yet not clear. Objective: To compare the levels of serum trace elements such as selenium, zinc, and copper between the patients with euthyroid nodular goiter and healthy participants. Methods: This cross‑sectional study included 98 patients with euthyroid multinodular goiter and 83 healthy subjects without thyroid disease. The demographics, thyroid hormone levels, and thyroid ultrasonography of the participants were recorded. Venous blood samples were centrifuged and sera samples were stored at ˗80°C until analysis of selenium, zinc, and copper levels. The levels of trace elements were determined by inductively coupled plasma‑mass spectrometry (ICP‑MS). Results: While serum, zinc, and selenium levels were significantly higher in the control group than the nodular goiter group, the copper levels were similar in the two groups. Trace elements were not correlated with thyroid hormone levels and thyroid volumes. Patients in the nodular goiter group were analyzed according to their solitary and multiple nodule status. The solitary and multiple nodular goiter groups were similar in terms of copper, zinc, and selenium levels. Conclusions: Deficiency of selenium and zinc may be associated with nodular goiter. Replacement of these trace elements may be useful for the prevention of nodular goiter, especially in deficient regions.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2457http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2457/717718296

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Estimation of Cardiovascular Disease Risk Factors in the Undefined Participants of Campaign in Isfahan in 201724582458ENDepartment of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Hezar‑Jarib Ave, IsfahanDepartment of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Hezar‑Jarib Ave, IsfahanDepartment of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Hezar‑Jarib Ave, Isfahan20210908Background:The cardiovascular mortality rate in Iran has been reported 65% of all death recently. Despite the high prevalence of cardiovascular diseases(CVD) risk factors and its burden in developing countries, public awareness of CVD symptoms and its risk factors are very low, leading to poor control of these risk factors. Methods: Our study is a cross‑sectional study that was conducted in an undefined sample of 163 individuals who participated in a public health campaign. We used a validated questionnaire containing demographic, cardiovascular history, family history, lifestyle (exercise, smoking, alcohol, and environment), stress, sleep, bowel toxicity, blood sugar, inflammation/pain, and diet parts for estimating total cardiovascular risk factor. Results: 52.7% of our participants were male. The mean age of our participants was 42.6±47.27years. Half of our participants(50.3%) were between 30 and 60years. 12.3% of the participants were diagnosed with CVD. 12.8% were smokers and 25.8% were passive smokers. 73% of our participants had a high level of stress in their individual and work life. 35.5% of participants sleep less than 6 h per night. Half of them complained of initial or intermittent insomnia. 51.5% of our participants were at high or very high risk for CVD with three or more relative risks. There was a significant association between total cardiovascular risk and blood pressure, weight, sleep, and lifestyle in our population. Conclusions: More than half of our participants were on high or very high risk for CVD.The most common risk of CVD events in our participants is attributed to hypertension. Weight, sleep, and lifestyle were other modifiable risks that had a significant association with CVD in our study.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2458http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2458/717718297

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Comparison of Gastrointestinal Complications of Paracetamol and Ibuprofen in the Management of Infants with Patent Ductus Arteriosus: A Randomized Clinical Trial Study24592459ENDepartment of Pediatric, Semnan University of Medical Science, Semnan & Students Research Committee, Semnan University of Medical Science, SemnanDepartment of Pediatric, Semnan University of Medical Science, SemnanSocial Determinants of Health Research Center, Semnan University of Medical Science, SemnanDepartment of Pediatric, Semnan University of Medical Science, Semnan20210908Background: Patent ductus arteriosus(PDA) is one of the more common congenital heart defects in preterm neonates. The closure of PDA can be done with ibuprofen; however, this drug is associated with many contraindications and potential side‑effects. In the past years, paracetamol has been proposed for the treatment of PDA. This study was designed to evaluate the efficacy and gastrointestinal complications of paracetamol and ibuprofen for the pharmacological closure of PDA in preterm infants. Methods: In a clinical trial study, 40 preterm infants with echocardiographically confirmed PDA were randomly assigned to receive either paracetamol (n=23; 15mg/kg every 6 h for 2days) or ibuprofen(n=17; initial dose of 10mg/kg, followed by 5mg/kg every 12 h for 2days). The neonates matched for gestational age and weight. We used t‑test for parametric, Chi‑square for categorial, and Wilcoxson for nonparametric variables. Significant level was considered less than 0.05. Results: Platelet count, BUN and creatinine levels, and closure of PDA had not significant difference between two groups(P>0.05). Incidence and severity of GI bleeding, feeding intolerance, and NEC were significantly more in infants who received paracetamol than ibuprofen(P<0.05). Conclusions: There were no differences in the rate of PDA closure between the two drugs, but with respect to complications, rate and severity of GI bleeding, feeding intolerance, and NEC were significantly more in infants who received paracetamol than ibuprofen. Therefore, paracetamol could not be used as a proper alternative agent for ibuprofen in the treatment of PDA in preterm infantshttp://ijpm.mui.ac.ir/index.php/ijpm/article/view/2459http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2459/717718298

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Psychometric Properties of the Persian Version of the PARADISE‑24 Questionnaire24612461ENMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, TehranMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, TehranDepartment of Neurology, Shahid Beheshti University of Medical Sciences, TehranDepartment of Neurology, Shahid Beheshti University of Medical Sciences, TehranMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, TehranMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, TehranUniversal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran20210908Background: Patients with multiple sclerosis(MS) suffer from a wide range of psychological problems. Application of a valid and reliable tool for psychosocial assessment is required for Iranian patients. The aim of this study is to determine the psychometric properties of the Persian version of the PARADISE‑24 questionnaire in Iranian patients with multiple sclerosis. Methods: One hundred and thirteen multiple sclerosis cases were enrolled in this study. Participants were asked to answer the valid and reliable Persian version of the fatigue severity scale, social support scale, Pittsburg sleep quality index, and hospital anxiety and depression scale and translated version of the PARADISE‑24 questionnaire. Twenty cases filed the questionnaire 2weeks later to assess reliability. The intraclass correlation coefficient, Cronbach’s alpha, correlation coefficients, and multiple regression analysis were used. Results: Mean age and mean duration of the disease were 35.8±9.9 and 8.7±5.6years, respectively. The intraclass correlation coefficientsranged from 0.8 to 0.94 and Cronbach’s alpha values(Cronbach’s alpha was calculated as 0.91 for the whole questionnaire) were also significant. There were significant correlations between PARADISE‑24 score and expanded disability status scale(r=0.42, P<0.001), fatigue severity scale(r=0.62, P<0.001), anxiety(r=0.43, P<0.001) and Pittsburg sleep quality index scores(r=0.46, P<0.001). Regression analysis by considering PARADISE‑24 as dependent and other variables as independent showed that expanded disability status scale, fatigue severity scale, anxiety score, and Pittsburg sleep quality index were positive predictors of PARADISE‑24 score. Conclusions: Persian version of PARADISE‑24 questionnaire is a valid and reliable instrument for evaluating psychosocial aspects in patients with multiple sclerosis.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2461http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2461/717718300

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Construction and Examination of an Early Childhood Development Composite Index: Evidence from Iran’s Multiple Indicator Demographic and Health Survey24622462ENSocial Determinants of Health Research Center, Isfahan University of Medical Sciences, IsfahanDepartment of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, IsfahanHealth Management and Economics Research Center, Isfahan University of Medical Sciences, IsfahanDepartment of Communication Sciences, Imec‑mict‑Ghent University, Ghent20210913Background: Assessing children’s early development can help health and social policymakers to improve children’s well‑being. This study aims to develop an early childhood composite index for measuring early childhood care and education among Iranian children considering each child’s geographical area, socioeconomic status and gender. Methods: In this cross‑sectional secondary study, the data come from Iran’s Multiple Indicator Demographic and Health Survey 2010. Of the 9,345 eligible children whose information had been collected, 3,532 fulfilled the inclusion criterion of being 3 or 4 years old at the time of the interview. We examined a composite index and three subscales of early childhood development including “Quality of Care”, “Early Childhood Care and Education”, and “Overall Developmental Status”. Factor analysis and latent class analysis were used for analyzing the data.Results: The results indicate that of the children in the sample, 47.3% were in the “low early child development” class, 6% were in the “middle early child development” class, and 46.7% were in the “high early child development” class. The means of the three subscales and the composite index were significantly different across geographical areas (P < 0.01) and between the socioeconomic classes (P < 0.0001), with children from poorer families having lower scores. The composite index was significantly higher for girls (M = 11.28, SD = 3.96) than boys (M = 10.99, SD = 3.87, P = 0.029).Conclusions: The study presents significant differences in childhood development based on geographical divisions, quartile classes and gender. We suggest that future research is needed to explore the robustness of findings in this study over time and diversity between and within various Iranian populations.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2462http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2462/717718301

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Independent and Combined Effects of Calcium and Vitamin D Supplementation on Blood Lipids in Overweight or Obese Premenopausal Women: A Triple‑Blind Randomized Controlled Clinical Trial24632463ENResearch Center of Nutrition and Food Sciences, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, ShirazDepartment of Physical Education and Sport Physiology, Shiraz University, ShirazFaculty of Community Services, School of Nutrition, Ryerson University, Toronto, ONResearch Center of Nutrition and Food Sciences, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz20210913Background: Dyslipidemia is often associated with obesity and contributes to the increased risk of atherosclerosis, heart disease, and stroke. This study was designed to evaluate the independent or combined effect of calcium and vitamin D (Ca + Vit D) supplementation on blood lipid profile in overweight or obese premenopausal women.Methods: This study is a triple‑blind, randomized, parallel, placebo‑controlled trial. About 100 overweight or obese (body mass index (BMI) of 25–40 kg/m2 ) premenopausal (aged 30–50 years) women, recruited from Shiraz University of Medical Sciences (SUMS) clinics, were allocated into 4 groups: (1) calcium (Ca) supplementation (2 tablets per day; each containing 500 mg calcium carbonate), (2) vitamin D (Vit D) supplementation (2 tablets per day; each containing 200 IU vitamin D3), (3) Ca + Vit D supplementation (2 tablets per day; each containing 500 mg calcium carbonate plus 200 IU vitamin D3), (4) placebo supplementation (2 tablets per day, containing micro‑cellulose). All participants received a 500 kcal energy‑restricted diet. Blood lipids, serum vitamin D, and anthropometric indices were measured at baseline and after 8 weeks. Physical activity and 3‑day dietary records were taken at baseline and every 4 weeks during the intervention.Results: At 8 weeks, triglyceride levels were significantly decreased in the Ca group (P = 0.002). Low‑density lipoprotein (LDL) levels were decreased in the Ca + Vit D group (P = 0.04) and high‑density lipoprotein (HDL) levels decreased in both the Ca and Ca + Vit D groups (P = 0.006, P = 0.004, respectively). The results of one‑way ANOVA indicated that changes in the serum lipid profile levels were not significantly different among the four groups (P = 0.90, P = 0.86, P = 0.61, P = 0.27, and P = 0.19, respectively for TG, TC, LDL, HDL, and LDL/HDL). The results were not significant even after adjusting for potential covariates.Conclusions: Although the results were not significantly different among the four treated groups at 8 weeks, within‑group changes like the reduction in triglyceride and LDL levels, respectively in the Ca group and Ca + Vit D group, and HDL levels in both the Ca and Ca + Vit D groups were significant. These changes may have potentially significant public health implications.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2463http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2463/717718302

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Mapping the Relative Risk of Congenital Hypothyroidism Incidence via Spatial Zero-Inflated Poisson Model in Guilan Province, Iran24642464ENDepartment of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, TehranPediatric Diseases Research Center, Guilan University of Medical Sciences, RashtEnglish Language Department, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, TehranDepartment of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, TehranDepartment of Biostatistics, Proteomics Research Center, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran20210913Background: Congenital hypothyroidism (CH) is one of the most prevalent preventable causes of mental retardation. Studies show that the incidence rate of CH is very high in Iran. Disease mapping is a tool for visually expressing the frequency, incidence, or relative risk of illness. The present study aimed to model CH counts considering the effects of the neighborhood in towns and perform mapping based on the relative risk.Methods: In this historical cohort study, data of all neonates diagnosed with CH with TSH level ≥5 mIU/L between March 21, 2017, and March 20, 2018, in health centers in Guilan, Iran were used. The number of neonates with CH was zero in most towns of Guilan Province. The Bayesian spatial zero-inflated Poisson (ZIP) regression model was employed to investigate the effect of the town’s neighborhood on the relative risk of CH incidence. Then, the map of the posterior mean of the relative risk for CH incidence was provided. The analysis was performed using OpenBUGS and Arc GIS software programs.Results: The relative risk of CH incidence was high in the West of Guilan. Moreover, the goodness-of-fit criterion indicated that it is more appropriate to fit the Bayesian spatial ZIP model to these data than the common model.Conclusions: Considering the high relative risk of CH in the Western towns of Guilan Province, it is better to check important risk factors in this region.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2464http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2464/717718305

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Breast Cancer Incidence Trends in Isfahan Province Compared with those in England over the Period 2001–201324652465ENIlam University of Medical Sciences, IlamSchool of Public Health, Isfahan University of Medical Sciences, IsfahanIsfahan University of Medical Sciences, IsfahanDepartment of Cancer Prevention Research Centre and Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan20210914Background: Figures from Iranian cancer registries indicate that Isfahan ranks first in female breast cancer incidence. Although few previous studies have examined whether the breast cancer incidence trend in Isfahan province has increased over a given period of time, this study employed a joint point regression analysis to answer the same question. Moreover, it compared the data of Isfahan province, from a developing country, with those of England, as a representative of developed countries, and tried to explain the causes of the differences observed between the trends.Methods: This repeated cross‑sectional study was conducted on the data of 6057 women in Isfahan province and of 141,011 women in England with breast cancer over the years 2001–2013. The incidence rates were calculated using direct standardization method and based on the 2013 standard European population. For an analysis of the trends in breast cancer incidence rates, Joint Point Regression program, version 4.3.1.0, released in April 2016, was employed.Results: The mean age‑standardized incidence rate (ASR) was calculated to be 34.7 per100,000 population over the years 2001 to 2013, which indicated an increase from 22 to 68 in Isfahan province. The corresponding mean ASR for England has also risen from 147.5 to 170.1 per 100,000 women during the same time period. The average annual percentage changes (AAPCs) for Isfahan and England were also calculated to be 9.6 and 1.1, respectively. This indicated an increasing trend in breast cancer incidence rates for Isfahan province over the period in question.Conclusions: The drastic discrepancy in breast cancer incidence rates between these two regions may be attributed to differences in an improved cancer registry system in Iran and women’s developing awareness of the cancer over time.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2465http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2465/717718306

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Effect of Yoga Intervention in the Management of Hypertension: A Preventive Trial24672467ENDepartments of Community Medicine Mumbai, Maharashtra,Departments of Community Medicine Mumbai, Maharashtra,Medicine, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra20210914Background: Noncommunicable diseases are on the rise in India. Hypertension is one of the major risk factors for cardiovascular diseases and also labeled as a chronic lifestyle disorder. Hence, non‑pharmacological interventions leading to lifestyle modifications are of utmost importance to control and prevent hypertension. This trial aims to implement yoga intervention to the experimental group in addition to medicines, advice on diet and physical activity and to compare blood pressure and perceived stress scores with the control group. Methods: It was an open‑label, two‑armed, non‑randomized controlled trial, conducted at a tertiary care center on 145 patients with hypertension: 73 in the intervention group and 72 in the control group. The intervention group received yoga intervention for a period of 4 months on a weekly basis along with advice on physical activity, diet, and routine medicines. The control group did not receive yoga intervention.Results: The mean age of the participants was 51.3 ± 9.4, females (58.2%) outnumbered males (41.3%). Following the intervention, perceived stress score and blood pressure showed a significant reduction between two groups (P < 0.001). Also, perceived stress and blood pressure were found to be reduced significantly within both groups (P < 0.001).Conclusions: Yoga proves to be an effective, safe, and less expensive adjunct therapy for hypertension management. Yoga was also found to be effective in reducing the level of stress. Diet modification and physical activity have got an important role to play in the control and prevention of hypertension.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2467http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2467/717718307

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Social Awareness of Whole Grains and the Feasibility of Replacement with Refined Grains: A Qualitative Study24682468ENDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics Non‑Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, TehranDepartment of Global Health and Population & Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MANon‑Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, TehranSocial Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, SanandajDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MADepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, TehranDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, TehranMinimally Invasive Surgery Research Center, Iran University of Medical Sciences, TehranDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran20210929Background: A correlation between type 2 diabetes and refined carbohydrates has been proven, while several studies have indicated that Iranian daily diets are poor in term of proper carbohydrates. It was thus considered absolutely critical to conduct a qualitative study in terms of people’s attitudes toward whole grains, and the feasibility of their replacing existing refined carbohydrates in their diets. The aim of this study is to probe Iranian awareness of whole grains, to explore barriers to refined‑grain substitution with whole grains and legumes, and to assess whole‑grain sensory perceptions. Methods: Focus group discussions (FGDs) and taste tests conducted between July 2016 and March 2017 in urban and rural areas of Kurdistan, Yazd, and Tehran provinces in Iran. A total of 96 healthy men and women (aged 40‑65, BMI ≥25 kg/m2 ) were selected through purposive sampling with maximum variation. FGDs were categorized by content analysis method. As for taste test, ANOVA analysis with Bonferroni post‑hoc was used to determine significant differences (P < 0.05). Results: Four themes and 11 sub‑themes emerged. Cultural beliefs, traditional eating patterns, sensory properties, and familial acceptance were the most influential factors in choosing the type of bread and rice. Simultaneously they are the most prominent barriers to consuming whole grains and legumes. Plain cooked brown rice had the lowest mean sensory attribute score and traditional whole‑wheat flatbread was the highest. Conclusions: There was a higher acceptance tendency toward using traditional whole‑wheat flatbread rather than refined grains, as it was consistent with preference and priority. However, low availability was the largest substitution problem.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2468http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2468/717718308

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Continuity of Primary Care in the Brazilian Amazon: A Cross‑Sectional Population‑Based Study24692469ENFaculty of Pharmaceutical Sciences, State University of Campinas, CampinasFaculty of Pharmaceutical Sciences, State University of Campinas, CampinasDepartment of Nursing in Public Health, Federal University of Pelotas, PelotasDepartment of Preventive Medicine, Universidade de São Paulo, Coordinator, Primary Care Research Group, Faculdade de Medicina Santa Marcelina, São Paulo4 Post‑Graduation Program of Pharmaceutical Sciences, Universidade de Sorocaba, Sorocaba20210929Background: Few studies have evaluated the continuity of primary care in universal health care systems, especially in underserved areas. Methods: This was a cross‑sectional study with 4,001 adults (≥18 years old) living in the Manaus Metropolitan Region in 2015. Interviews were conducted in households selected with probabilistic sampling. City and neighborhood variables were collected from databanks. Prevalence ratios (PR) of the continuity of care (defined as using a primary care service and having been previously registered in the Family Health Strategy program) and 95% confidence intervals (CIs) were calculated with multilevel Poisson regression analysis. Results: A total of 20.6% (95%CI 19.4‑21.9%) of the participants reported continuity of primary care. Women (PR = 1.38; 95%CI 1.18‑1.61), nonwhite individuals (PR = 1.13; 95%CI 1.05‑1.21), and poorer people (PR = 1.55; 95%CI 1.19‑2.02) had higher levels of continuity, whereas health insurance holders had lower levels of continuity (PR = 0.46; 95%CI 0.34‑0.62). Individuals with continuity of care had more physician consultations (PR = 1.06; 95%CI 1.02‑1.10), dentist consultations (PR = 1.16; 95%CI 1.05‑1.28), fewer depressive (PR = 0.59; 95%CI 0.44‑0.79) and anxiety symptoms (PR = 0.64; 95%CI 0.48‑0.85), and a higher quality of life (β = 0.033; 95%CI 0.011‑0.054) than those without continuity. Conclusions: Continuity of care was attained by two‑tenths of the population and the level of continuity was high among socioeconomically disadvantaged people. Good outcomes and health services usage increased with continuity of care.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2469http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2469/717718309

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Stool Examination for Liver Fluke Detection and Ultrasonography for Detection of Abnormal Biliary Tract in Cholangiocarcinoma Control Program: A Reappraisal from Endemic Area in Indochina24542454ENKMT Primary Care Center, BangkokDr. DY Patil University, Pune, Maharashtra20210903Sir, cholangiocarcinoma is a deadly malignancy of biliary tract that has its highest prevalence in Indochina. The patients usually present with severe hyperbilirubinemia with grave prognosis.The relationship between cholangiocarcinoma and liver fluke infection is widely mentioned.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2454http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2454/717718293

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Role of Sports in Social Health Promotion24552455ENDepartment of Biomedicine and Prevention, Physical Activity and Health Promotion, Faculty of Medicine and Surgery, University of Roma Tor Vergata, Via Montpellier, Roma RM20210908Dear Editor, Sports in a social context can be defined as a type of leisure‑time physical activity(PA), organized to improve physical, social, emotional, and mental well‑being among the participants.http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2455http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2455/717718294

International Journal of Preventive Medicine (Int J Prev Med)2008-780212520210929Expected RATE of Vaccine‑Associated Paralytic Poliomyelitis: A Simulation Analysis Regarding Transition from the Trivalent to Bivalent Oral Poliovirus Vaccine24602460ENPrivate Academic PracticeHonorary Professor, Dr. DY Patil University, Pune, Maharashtra20210908Dear Editor,Poliomyelitis is a preventable infection by vaccine. At present, natural disease exists in some countries, especially those in Africa. The vaccine‑associated paralytic poliomyelitis(VAPP) is an unwanted adverse event of vaccination. http://ijpm.mui.ac.ir/index.php/ijpm/article/view/2460http://ijpm.mui.ac.ir/index.php/ijpm/article/download/2460/717718299