A Literature Review on the Efficacy and Safety of Botulinum Toxin: An Injection in Post‑Stroke Spasticity

Majid Ghasemi, Mehri Salari, Fariborz Khorvash, Vahid Shaygannejad


Background: A variety of techniques for the management of spasticity have been suggested, including positioning, cryotherapy, splinting and casting, biofeedback, electrical stimulation, and medical management by pharmacological agents, Botulinum toxin A (BTA) is now the pharmacological treatment of choice in focal spasticity. BTA by blocking acetylcholine release at neuromuscular junctions accounts for its therapeutic action to relieve spasticity.

Methods: A computerized search of Pub Med was carried out to find the latest result about efficacy of BTA in management of post stroke spasticity.

Result: Among 84 articles were found, frothy of them included in this review and divided to lower and upper extremity.

Conclusions: BTA is a treatment choice in reducing tone and managing post stroke spasticity.

Keywords: Botulinum toxin A, spasticity, stroke

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