Controlling Lipids AIDS in the Prevention of Type 2 Diabetes, Hypertension, and Cardiovascular Diseases

Abstract

Background: Abnormal lipid profles are a characteristic feature of persons with chronic conditions in which the diabetic populations are recognized as the dominant group, regardless of gender and ethnicity worldwide. This study was conducted to identify and evaluate the abnormalities of serum
lipid profles in both nondiabetic and diabetic persons.

Methods: This study was a case–control investigation conducted between 2013 and 2015. The study enrolled 266 patients from the North Central and South West Regional Health Authorities of Trinidad. Of the 266 patients recruited, 126 were diabetic and 140 were nondiabetic.

Results: Our study observed that dyslipidemia was present among the nondiabetic populations as the nondiabetics had 55 women and 20 men with high cholesterol, 22 women and 14 men with high triglyceride (TG), 30 women and 25 men with low high‑density lipoprotein cholesterol (HDL‑C), 42 women and 21 men with high low‑density level‑cholesterol (LDL‑C), 13 women and 8 men with high very low‑density lipoprotein (VLDL), and also 30 women and 11 men with body mass index (BMI) over 30 kg/m². We also observed that diabetic women had signifcantly lower TGs (P = 0.019) and higher HDL‑C (P = 0.001) and LDL (P = 0.003) when compared with the diabetic men. In addition, the nondiabetic females also had higher HDL‑C (P = 0.045) when compared to their male counterparts. Both diabetic and nondiabetic women exhibited signifcantly higher BMI of P = 0.000. A negative correlation was obtained among TGs and HDL (r = -0.356, n = 83, P = 0.001) and a positive correlation was observed among LDL and HDL (r = 0.230, n = 86, P = 0.035).

Conclusions: This study observed the incidences in the abnormalities of serum lipid profles in both nondiabetic and diabetic persons. It also presents the high occurrence of nondiabetic women with dyslipidemia as they presented with high cholesterol, high TG, low HDL‑C, and high VLD‑L with BMI over 30 kg/m².

Keywords: Abnormal lipid profle, middle‑aged, nondiabetic, type 2 diabetic, weight